Hydrocephalus is characterized by enlargement of the cerebral ventricles, accompanied by distortion of the periventricular tissue. Patients with hydrocephalus usually experience urinary impairments. Although the underlying etiology is not fully described, the effects of hydrocephalus in the neuronal network responsible for the control of urination, which involves periventricular areas, including the periaqueduc...
In early 2020, the COVID-19 pandemic forced the higher education institutions to adapt to a new form of teaching and learning, from presential to full remote, blended and hybrid environment.
Neurological impairments may affect the neural control of the Lower Urinary Tract (LUT), due to structural and functional changes. Hydrocephalic patients usually present a triad of symptoms, which include gait disturbances, dementia and urinary incontinence. The consequences of hydrocephalus in brain structures, namely those involved in neural control of micturition remain mostly unknown. We used a validated an...
Pain transmission at the spinal cord is modulated by noradrenaline (NA)-mediated actions that arise from supraspinal areas. We studied the locus coeruleus (LC) to evaluate the expression of the cathecolamine-synthetizing enzyme tyrosine hydroxylase (TH) and search for local oxidative stress and possible consequences in descending pain modulation in a model of hydrocephalus, a disease characterized by enlargemen...
Pain transmission at the spinal cord is modulated by descending actions that arise from supraspinal areas which collectively form the endogenous pain control system. Two key areas involved of the endogenous pain control system have a circunventricular location, namely the periaqueductal grey (PAG) and the locus coeruleus (LC). The PAG plays a crucial role in descending pain modulation as it conveys the input fr...
Dental caries, a progressive infection caused by microorganisms, remain one of the most common diseases throughout the world. The mouth is an ideal environment for bacteria, and one of the best-known for being responsible for dental caries is the Streptococcus mutans.