4 documents found, page 1 of 1
A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane
Loureiro, Cláudia Almeida; Pinto, Francisco R.; Barros, Patrícia; Matos, Paulo; Jordan, PeterMutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the recessive genetic disease cystic fibrosis, where the chloride transport across the apical membrane of epithelial cells mediated by the CFTR protein is impaired. CFTR protein trafficking to the plasma membrane (PM) is the result of a complex interplay between the secretory and membrane recycling pathways that control the n...
Tyrosine phosphorylation modulates cell surface expression of chloride cotransp...
Loureiro, Cláudia Almeida; Barros, Patrícia; Matos, Paulo; Jordan, PeterCellular chloride transport has a fundamental role in cell volume regulation and renal salt handling. Cellular chloride entry or exit are mediated at the plasma membrane by cotransporter proteins of the solute carrier 12 family. For example, NKCC2 resorbs chloride with sodium and potassium ions at the apical membrane of epithelial cells in the kidney, whereas KCC3 releases chloride with potassium ions at the ba...
Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane St...
Loureiro, Cláudia Almeida; Santos, João D.; Matos, Ana Margarida; Jordan, Peter; Matos, Paulo; Farinha, Carlos M.; Pinto, Francisco R.Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31231217/; In cystic fibrosis, the most common disease-causing mutation is F508del, which causes not only intracellular retention and degradation of CFTR, but also defective channel gating and decreased membrane stability of the small amount that reaches the plasma membrane (PM). Thus, pharmacological correction of mutant CFTR requires targeting o...
Regulação dos níveis de transportadores de cloreto na membrana plasmática de cé...
Loureiro, Cláudia AlmeidaTese de mestrado em Bioquímica (Bioquímica Médica), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012; A hipertensão arterial afeta, em países ocidentais, quase um terço da população adulta, sendo um fator de alto risco para a doença cardiovascular ou o acidente vascular cerebral. O pseudohipoaldosteronismo tipo II, ou síndroma de Gordon, é uma forma rara de hipertensão familiar, cara...