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The role of ethanol oxidation during carboxydotrophic growth of clostridium aut...
Diender, Martijn; Dykstra, James C.; Parera Olm, Ivette; Kengen, Servé W. M.; Stams, Alfons Johannes Maria; Sousa, Diana Zita MachadoThe WoodLjungdahl pathway is an ancient metabolic route used by acetogenic carboxydotrophs to convert CO into acetate, and some cases ethanol. When produced, ethanol is generally seen as an end product of acetogenic metabolism, but here we show that it acts as an important intermediate and co-substrate during carboxydotrophic growth of Clostridium autoethanogenum. Depending on CO availability, C. autoethanogenu...
Genetically manipulated phages with improved pH resistance for oral administrat...
Nóbrega, Franklin Luzia; Costa, Ana Rita; Santos, J.; Siliakus, Melvin F.; van Lent, Jan W. M.; Kengen, Servé W. M.; Azeredo, Joana; Kluskens, LeonOrally administered phages to control zoonotic pathogens face important challenges, mainly related to the hostile conditions found in the gastrointestinal tract (GIT). These include temperature, salinity and primarily pH, which is exceptionally low in certain compartments. Phage survival under these conditions can be jeopardized and undermine treatment. Strategies like encapsulation have been attempted with rel...