24 documents found, page 1 of 3
Lipid nanoparticle formulations via nose-to-brain for the treatment of Alzheime...
Silva, Ana Catarina; Loureiro, Joana; Soage , JuanAlzheimer’s and Parkinson’s diseases are currently identified as the most prevalent neurodegenerative diseases, constituting a public health problem. Pharmacological therapy for the treatment of these diseases is limited by the low bioavailability of drugs in the central nervous system. In recent years, it has been reported that intranasal administration of formulations via the direct nose-to-brain route shows ...
Screen-printed, flexible, and eco-friendly thermoelectric touch sensors based o...
Figueira, J.; Bonito, R. M.; Carvalho, J. T.; Vieira, E. M. F; Gaspar, C.; Loureiro, Joana; Correia, J. H.; Fortunato, E.; Martins, R.; Pereira, L.Despite the undoubtable interest in energy conversion, thermoelectric (TE) materials can be approached from a temperature-sensitive perspective, as they can detect small thermal stimuli, such as a human touch or contact with cold/hot objects. This feature offers possibilities for different applications one of them being the integration with scalable and cost-effective, biocompatible, flexible, and lightweight t...
Composites based on PDMS and graphite flakes for thermoelectric sensing applica...
Figueira, Joana; Vieira, E. M. F; Loureiro, Joana; Correia, J. H.; Fortunato, Elvira; Martins, Rodrigo; Pereira, Luís[Excerpt] Thermoelectric (TE) devices are utilized for thermal energy harvesting, local cooling or heating, and temperature sensing. They have no mechanical structures, can be made flexible and present long operating lifetimes, making them useful for the Internet of Things (IoT) and wearable electronics.[...]
Methods for the Measurement of Early Events in Toxoplasma gondii Immunity in Mo...
Alvarez, Catalina; Campos, Ana Claudia; Howard, Jonathan C; Loureiro, Joana; Müller, Urs Benedikt; Rodrigues, Ana LinaCritical steps in resistance of mice against Toxoplasma gondii occur in the first 2 or 3 h after the pathogen has entered a cell that has been exposed to interferon γ (IFNγ). The newly formed parasitophorous vacuole is attacked by the IFNγ-inducible IRG proteins and disrupted, resulting in death of the parasite and necrotic death of the cell. Here we describe some techniques that we have used to describe and qu...
Alzheimer’s disease: Development of a sensitive label-free electrochemical immu...
Carneiro, Pedro; Loureiro, Joana; Delerue-Matos, Cristina; Morais, Simone; Pereira, Maria do CarmoIn this work, a highly sensitive label-free immunosensor for detection of the main biomarker of Alzheimer’s disease (AD), amyloid beta 1–42 (Aβ (1–42)), is presented. A gold electrode was modified with a mercaptopropionic acid (MPA) self-assembled monolayer, electrodeposited gold nanoparticles (AuNPs) and a monoclonal antibody mAb DE2B4 to recognize Aβ; all the relevant experimental variables were optimized. An...
Metal alloys, matrix inclusions and manufacturing techniques of Moinhos de Gola...
Loureiro, Joana; Figueiredo, Elin; Silva, Rui J. C.; Araújo, M. Fátima; Fonte, João; Bettencourt, Ana M. S.A collection of 35 metallic artefacts comprising various typologies, some of which can be attributed to the Bronze Age and others to later periods, were studied to provide detailed information on elemental composition, manufacturing techniques and preservation state. Elemental analysis by micro-EDXRF and SEM–EDS was performed to investigate the use of different alloys and to study the presence of microstructura...
Alzheimer’s disease: Development of a sensitive label-freeelectrochemical immun...
Carneiro, Pedro; Loureiro, Joana; Delerue-Matos, Cristina; Morais, Simone; Pereira, Maria do CarmoIn this work, a highly sensitive label-free immunosensor for detection of the main biomarker of Alzheimer’s disease (AD), amyloid beta 1–42 (A (1–42)), is presented. A gold electrode was modified with a mercaptopropionic acid (MPA) self-assembled monolayer, electrodeposited gold nanoparticles (AuNPs) and a monoclonal antibody mAb DE2B4 to recognize A ; all the relevant experimental variables were optimized. Anti...
Texto e contexto no QECRL e nas propostas dos manuais: explorando as condições ...
Loureiro, JoanaEsta dissertação pretende ser um contributo para o ensino de Português (PLE/PL2), designadamente no ensino da leitura e da escrita. O estudo adota como fundamento teórico as propostas de ensino conhecidas por Pedagogia de Género (Martin e Rose, 2008; Rose e Martin, 2012), por sua vez baseadas nos estudos genológicos (Christie, 1998; Martin e Rothery, 1986; Christie e Martin, 1997; Martin, 1999). Partindo da con...
Gamma distribution model in breast cancer diffusion-weighted imaging
Borlinhas, Filipa; Nogueira, Luisa; Brandao, Sofia; Nunes, Rita G.; Loureiro, Joana; Ramos, Isabel; Ferreira, Hugo ASummary form only given. Many diffusion models have been proposed in order to obtain more information from breast tumor tissues through Magnetic Resonance Imaging (MRI) (1). The Gamma distribution (GD) may model MRI signal decay based on a statistical approach. This model considers the Theta parameter, which indicates the statistical dispersion of the distribution, and the k parameter, which is responsible for ...
Breast DWI at 3 T: influence of the fat-suppression technique on image quality ...
Nogueira, Luisa; Brandão, Sofia; Nunes, Rita G.; Ferreira, Hugo Alexandre; Loureiro, Joana; Ramos, IsabelAim To evaluate two fat-suppression techniques: short tau inversion recovery (STIR) and spectral adiabatic inversion recovery (SPAIR) regarding image quality and diagnostic performance in diffusion-weighted imaging (DWI) of breast lesions at 3 T. Materials and methods Ninety-two women (mean age 48 ± 12.1 years; range 21–78 years) underwent breast MRI. Two DWI pulse sequences, with b-values (50 and 1000 s/mm2) w...