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In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based n...

Fonseca-Gomes, João; Loureiro, Joana A; Tanqueiro, Sara; Mouro, Francisco; Ruivo, Pedro; Carvalho, Tânia; Sebastião, Ana M; Diógenes, Maria José

Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (H...


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