7 documents found, page 1 of 1
Hippocampal cell cytogenesis in Health and stress-induced Depression: insights ...
Loureiro-Campos, EduardoA génese celular no cérebro de mamífero adulto desafiou o dogma de longa data de que o sistema nervoso central adulto era imutável e incapaz de gerar novas células. É amplamente aceite que o cérebro adulto possui habilidades dinâmicas de remodelação axodendrítica, bem como a capacidade de produzir novas células neuronais e gliais ao longo da vida em regiões restritas do cérebro, processo conhecido como neuroe g...
Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astroglio...
Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Patrício, Patrícia; Araújo, Bruna Alexandra Vale; Alves, Nuno Dinis; Mateus-Pinheiro, AntónioDepression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, l...
Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into n...
Pinheiro, Bárbara Filipa Mendes; Cunha, Carina Isabel Soares; Marote, Ana Maria Franco Aveiro; Loureiro-Campos, Eduardo; Campos, Jonas OliveiraParkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson’s disease (PD) in rodents. Despite commonly used in rats, it can be challenging to reproduce a similar lesion in mice. Moreover, there is a lac...
Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes a...
Loureiro-Campos, Eduardo; Mateus-Pinheiro, António; Patrício, Patrícia; Cunha, Carina Isabel Soares; Silva, Joana; Sardinha, Vanessa Alexandra MoraisThe transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early post...
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Soares-Cunha, Carina; Vasconcelos, Nivaldo António Portela; Coimbra, Bárbara; Domingues, Ana Verónica; Silva, Joana M.; Loureiro-Campos, EduardoDeficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying the underlying neural circuits in detail. One of the key regions of the reward circuit is the nucleus accumbens (NAc). The classical view on the field postulates that NAc dopamine receptor D1-expressing medium spiny neurons (D1-MSNs) co...
Chronic stress targets adult neurogenesis preferentially in the suprapyramidal ...
Alves, Nuno D.; Patrício, Patrícia; Correia, Joana S.; Mateus-Pinheiro, António; Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Morais, MónicaThe continuous generation of new neurons and glial cells in the adult hippocampal dentate gyrus (DG) represents an important form of adult neuroplasticity, involved in normal brain function and behavior but also associated with the etiopathogenesis and treatment of psychiatric disorders. Despite the large number of studies addressing cell genesis along the septotemporal axis, data on the anatomical gradients of...
Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
Alves, Nuno Dinis Lopes Oliveira; Silva-Correia, Joana; Patrício, Patrícia Carvalho; Pinheiro, António Maria Restolho Mateus; Machado-Santos, Ana R.Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neur...