393 documents found, page 1 of 40

A regulatory perspective on the applicability of NAMs in genotoxicity and carci...

New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment. Even with substantial EU commitment from regulatory agencies and the academic community, the full regulatory adoption of NAMs remains a distant prospect. This challenge is further complicated by the fact that the academic world, orient...

Shaping the future of human biomonitoring (HBM)

Human biomonitoring (HBM) continues to play an indispensable role within exposure science, offering insights into aggregate chemical exposures across populations and life stages. Since 2018, the European chapter of the International Society of Exposure Science Human Biomonitoring Working Group (ISES Europe HBM WG) has aimed to facilitate generation of more and high-quality HBM data. The working group aims to st...

O ensaio do micronúcleo em células da mucosa bucal: aplicabilidade em biomonito...

As exposições ambientais e ocupacionais a alguns agentes químicos ou físicos representam sérios riscos para a saúde humana. A biomonitorização humana (BMH) permite quantificar a exposição a substâncias químicas e seus efeitos precoces através da caracterização de biomarcadores de exposição e de biomarcadores de efeito. O ensaio do micronúcleo em células bucais (MNBMCyt) é um biomarcador precoce de genotoxicidad...

HBM4EU chromates study: the Portuguese integrated and harmonized study on expos...

In the scope of the European Union (EU) human biomonitoring initiative, a multicentric study on different occupational settings from several European countries was performed, to provide information on occupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen. Biomonitoring approaches were used to obtain exposure data to support the implementation of new risk management measures and policy a...

Re‐evaluation of butane (E 943a), isobutane (E 943b) and propane (E 944) as foo...

The Panel on Food Additives and Flavourings (FAF) provides a scientific opinion re‐evaluating the safety of butane (E 943a), isobutane (E 943b) and propane (E 944) as food additives. Butane, isobutane and propane are short‐chain (C3–C4) alkanes, which are in gaseous state at room temperature. Their currently permitted use in food is in vegetable oil pan spray (for professional use only) and water‐based emulsion...

Biomonitorização humana e genotoxicidade ambiental: quatro décadas de investiga...

Hazard identification and characterization of leachable chemicals from plastic ...

A recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the env...

A regulatory perspective on the applicability of NAMs in genotoxicity and carci...

New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment. Even with substantial EU commitment from regulatory agencies and the academic community, the full regulatory adoption of NAMs remains a distant prospect. This challenge is further complicated by the fact that the academic world, orient...

Shaping the future of human biomonitoring (HBM): progress, strategy, and global...

Human biomonitoring (HBM) continues to play an indispensable role within exposure science, offering insights into aggregate chemical exposures across populations and life stages. Since 2018, the European chapter of the International Society of Exposure Science Human Biomonitoring Working Group (ISES Europe HBM WG) has aimed to facilitate generation of more and high-quality HBM data. The working group aims to st...

Re‐evaluation of pullulan (E 1204) as a food additive and new application for i...

The present opinion deals with the re‐evaluation of pullulan (E 1204) when used as a food additive and with the new application on the extension of use to several food categories. Pullulan (E 1204) is obtained by fermentation of a food‐grade hydrolysed starch with non‐genetically modified Aureobasidium pullulans ■■■■■. Based on the available information, the Panel considered that the manufacturing process of pu...