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Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19

Loyola, Mariana Braccialli de; Reis, Thaís Tereza Aguiar dos; Oliveira, Guilherme Xavier Lyra Malcher de; Palmeira, Julys da Fonseca

Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the most important proteases in the pathophysiology of Covid‐19: the transmembrane serine protease 2 (TMPRSS2) and the ...

Date: 2021   |   Origin: Oasisbr
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