4 documents found, page 1 of 1
Nanomedicine-based technologies and novel biomarkers for the diagnosis and trea...
Cano, Amanda; Turowski, Patric; Ettcheto, Miren; Duskey, Jason Thomas; Tosi, Giovanni; Sánchez-López, Elena; García, Maria Luisa; Camins, AntonioIncreasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to make up 50-80% of all cases. AD cases are expected to reach 131 million by 2050, and this increasing prevalence will critically burden economies and health systems in the next decades. There is currently no t...
Nanomedicine-based technologies and novel biomarkers for the diagnosis and trea...
Cano, Amanda; Turowski, Patric; Ettcheto, Miren; Duskey, Jason Thomas; Tosi, Giovanni; Sánchez-López, Elena; García, Maria Luisa; Camins, AntonioIncreasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to make up 50--80% of all cases. AD cases are expected to reach 131 million by 2050, and this increasing prevalence will critically burden economies and health systems in the next decades. There is currently no ...
Current advances in the development of novel polymeric nanoparticles for the tr...
Cano, Amanda; Sánchez-López, Elena; Ettcheto, Miren; López-Machado, Ana; Espina, Marta; Souto, Eliana B.; Galindo, Ruth; Camins, AntonioEffective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the bloodbrain barrier, and thus be instrumental in preclinical discovery and therapeutic intervention of ND diseases. Polymeric nanoparticles (PNPs) have shown great potential and versatility to encapsulate several compounds simultaneously in co...
Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticle...
Cano, Amanda; Ettcheto, Miren; Espina, Marta; Auladell, Carmen; Folch, Jaume; Kühne, Britta A; Barenys, Marta; Sánchez-López, Elena; Souto, Eliana B.Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntingtons disease (HD)-like symptoms in mice. Materials \& methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-admin...