2 documents found, page 1 of 1
Fibrin functionalization with synthetic adhesive ligands interacting with a6ß1 ...
Silva, J; Bento, AR; Barros, D; Laundos, TL; Sousa, SR; Quelhas, P; Sousa, MM; Pêgo, AP; Amaral, IFTo enhance fibrin hydrogel affinity towards pluripotent stem cell-derived neural stem/progenitor cells (NSPCs) and its capacity to support NSPC migration and neurite extension, we explored the tethering of synthetic peptides engaging integrin a6ß1, a cell receptor enriched in NSPCs. Six a6ß1 integrin ligands were tested for their ability to support integrin a6ß1-mediated adhesion of embryonic stem cell-derived ...
Three-dimensional culture of single embryonic stem-derived neural/stem progenit...
Bento, AR; Quelhas, P; Oliveira, MJ; Pêgo, AP; Amaral, IFIn an attempt to improve the efficacy of neural stem/progenitor cell (NSPC) based therapies, fibrin hydrogels are being explored to provide a favourable microenvironment for cell survival and differentiation following transplantation. In the present work, the ability of fibrin to support the survival, proliferation, and neuronal differentiation of NSPCs derived from embryonic stem (ES) cells under monolayer cul...