3 documents found, page 1 of 1
Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR...
Veloso Júnior, Paulo Henrique de Holanda; Simon, Karina Smidt; Castro, Raffael Júnio Araújo de; Coelho, Luísa Coutinho; Hurtado Erazo, Fabián AndresAntimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory and antimicrobial activities of peptides ToAP3 and ToAP4, AMPs from the venom of the Brazilian scorpion Tityus obscurus. To test the peptides’ activity, murine bone marrow-derived macrophages (BMDMs) or dendritic cells (BMDCs) were stimulated with peptides plus LP...
Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients
Lozano, Viviane Furlan; Lins, Tulio Cesar de Lima; Teixeira, Marcus de Melo; Vieira, Rodrigo G.; Blotta, Maria Heloisa de Souza LimaThe CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1...
Análise de polimorfismo no gene CTLA-4 em pacientes com paracoccidioidomicose
Lozano, Viviane FurlanDissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, 2008.; A proteína CTLA-4 é expressa principalmente em células T ativadas, possuindo um papel fundamental na resposta imune, exercendo efeito regulador na ativação de célula T através da sua ligação com as moléculas da família B7, as quais são expressas em células apresentadoras de antígenos. Polimorfismos no gene CTLA-4 têm sido associados ...