73 documents found, page 1 of 8
MicroRNAs in takotsubo syndrome: a systematic review of regulatory networks in ...
Sousa, Domingos; Martins, Filipa Abreu; Luís, Ângelo; Serralheiro, PedroMicroRNAs (miRNAs) have emerged as crucial regulators of gene expression and have been implicated in various physiological and pathological processes, including cardiovascular diseases. The clinical presentation, diagnostic criteria, and proposed pathophysiological mechanisms of Takotsubo Syndrome (TTS) are discussed, with an emphasis on the emerging evidence implicating miRNAs in its etiology and progression. ...
Comparative study of sample preparation procedures to determine the main compou...
Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Restolho, José; Fernández, Nicolás; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaIntroduction : Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. Objective :The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Methodology:Three sample pretreatment tech...
Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analys...
Luís, Ângelo; Amaral, Leonor; Domingues, F.C.; Pereira, L.; Cascalheira, JoséGliomas are aggressive brain tumors with poor prognosis even after surgical removal and radio-chemotherapy, stressing the urgency to find alternative therapies. Several preclinical studies evaluating the anticancer effect of curcumin in animal models of glioma are reported, but a systematic review with meta-analysis of these studies, considering the different experimental conditions used, has not been made up t...
Pullulan-Tween 40 emulsified films containing geraniol: production and characte...
Simões, Alexandra; Ramos, Ana; Domingues, F.C.; Luís, ÂngeloPetroleum-based plastics have been widely used as packaging materials because of their low-cost availability and good mechanical properties. However, the use of plastics has become restricted as they are highly resistant to biodegradation, causing environmental problems. This work aimed to produce and characterize emulsified pullulan films incorporating geraniol for application as food packaging materials with ...
The role of ayahuasca in cell viability and oxidative stress in gastric adenoca...
Gonçalves, Joana; Cascalheira, José; Valentão, Patrícia; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaAyahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,Ndimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This...
Propolis Protects GC-1spg Spermatogonial Cells against Tert-Butyl Hydroperoxide...
Duarte, Filipa Maia; Feijó, Mariana; Luís, Ângelo; Socorro, Sílvia; Maia, Cláudio J.; Correia, SaraPropolis is a natural resin produced by honeybees with plenty of pharmacologic properties, including antioxidant activity. Oxidative stress disrupts germ cell development and sperm function, with demonstrated harmful effects on male reproduction. Several natural antioxidants have been shown to reduce oxidative damage and increase sperm fertility potential; however, little is known about the effects of propolis....
Comparative study of sample preparation procedures to determine the main compou...
Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Restolho, José; Fernández, Nicolás; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaIntroduction Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. Objective The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Methodology Three sample pretreatment techniq...
The Role of Ayahuasca in Colorectal Adenocarcinoma Cell Survival, Proliferation...
Gonçalves, Joana; Feijó, Mariana; Socorro, Sílvia; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaThe psychedelic beverage ayahuasca is originally obtained by Banisteriopsis caapi (B. caapi) (BC) and Psychotria viridis (P. viridis) (PV). However, sometimes these plant species are replaced by others that mimic the original effects, such as Mimosa hostilis (M. hostilis) (MH) and Peganum harmala (P. harmala) (PH). Its worldwide consumption and the number of studies on its potential therapeutic effects has incr...
Deteção e quantificação dos principais constituintes de Ayahuasca com recurso a...
Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Restolho, José; Luís, Ângelo; Duarte, Ana Paula; Gallardo, EugeniaA Ayahuasca é uma bebida psicoativa originalmente consumida na bacia amazónica. Esta decocção possui N,N-dimetiltriptamina (DMT), responsável pelos efeitos psicoativos, e alcaloides β-carbolínicos, que inibem a Monoamina Oxidase A (MAO-A), permitindo que o DMT aceda ao sistema nervoso central. A legislação que regula o consumo de Ayahuasca é pouco rigorosa, uma vez que esta também é consumida em contexto religi...
The Effect of Food Processing on the Antioxidant Properties of Ipomoea batatas
Alves, Tiago; Luís, Ângelo; Duarte, Ana PaulaIt is known that heat treatment can lead to physical and chemical changes that can decrease or alter the properties of food. This work evaluated the influence on the antioxidant activity of boiling, pressure, and microwave cooking processes on three selected sweet potato varieties (purple, orange, and yellow). The samples were analyzed for total phenols and anthocyanin content and antioxidant capacity. The cook...