33 documents found, page 1 of 4
Microvascular, biochemical, and clinical impact of hyperbaric oxygen therapy in...
Martins-Mendes, Daniela; Costa, Raquel; Rodrigues, Ilda; Camacho, Óscar; Coelho, Pedro Barata; Paixão-Dias, Vítor; Luís, Carla; Pereira, Ana CláudiaBackground: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical and biological effects remain insufficiently characterized. This study aimed to evaluate the impact of HBOT on systemic biomarkers, local microvasculature, and clinical outcome...
Harvesting the power of green synthesis: gold nanoparticles tailored for prosta...
Oliveira, Marco; Sousa, André; Sá, Sara; Soares, Sílvia; Pereira, Ana Cláudia; Rocha, Ana Catarina; Pais, Patrick; Ferreira, Diogo; Almeida, CátiaBiosynthetic gold nanoparticles (bAuNPs) present a promising avenue for enhancing biocompatibility and offering an economically and environmentally responsible alternative to traditional production methods, achieved through a reduction in the use of hazardous chemicals. While the potential of bAuNPs as anticancer agents has been explored, there is a limited body of research focusing on the crucial physicochemic...
Fructose-Derived Carbon Dots as Selective Antitumor Agents in Breast Cancer The...
Magalhães, Sofia; Luís, Carla; Duarte, Abel J.This study explored a novel method using fructose-derived carbon dots (FCDs) for antitumor therapy in breast cancer (BC), marking a pioneering use of fructose as a carbon source for nanoparticle synthesis. BC, known for its complexity and heterogeneity, was chosen as a model due to its increasing mortality and incidence rates. The FCD synthesis involved the decomposition of fructose through microwave irradiatio...
On risk analysis of the use of Cannabinoids compounds as therapy in Dementia
Pereira, Eduardo; Fernandes, Rúben; Luís, Carla; Baylina, Pilar; BAYLINA MACHADO, PILARNowadays dementia pharmaceutical treatment has an unfavourable risk-benefit relation. New therapeutic approaches’ adoption is need due to the high prevalence of this condition. To evaluate the risk of using cannabinoids compounds as nonharmful therapeutic approach in dementia. A systematic literature review based on PRISMA was performed. PubMed and Clinical Trials database were used to collect articles between ...
Vascular dysfunction in adipose tissue: Its impact on type 2 diabetes and cancer
Silva, Daniela Rosendo; Aguiar, Gonçalo; Luís, Carla; Soares, Raquel; Coelho, Pedro; Coelho, PedroThe overgrowth of adipose tissue is a major trigger for the development of other metabolic disorders, like insulin resistance, hypertension, type 2 diabetes, cardiovascular disease, and cancer. Among the causes of this association lies the fact that increased adiposity is accompanied by a nonfunctioning vascular component. Accordingly, vascular dysfunction within the adipose tissue is common in obesity and asso...
A retrospective study in tumour characteristics and clinical outcomes of overwe...
Luís, Carla; Dias, João; Firmino‑Machado, João; Fernandes, Rute; Pereira, Deolinda; Baylina, Pilar; Fernandes, Rúben; Soares, RaquelObesity and breast cancer are two major pathologies closely associated with increasing incidence and mortality rates, especially amongst women. The association between both diseases have been thoroughly discussed but much is still to uncover. The aim of this study is to analyse tumour characteristics and clinical outcomes of overweight and obese women to disclosure potential associations and better understand t...
Unveiling the path to resilience: prioritizing mental health, sleep, and nutrit...
Ramalho, Susana; Martins-Mendes, Daniela; Macedo, José Mário; Barros, Carla; Luís, Carla; Sá, Sara; Gestoso, Álvaro; Pereira, Ana CláudiaThe COVID-19 pandemic has disrupted daily life, impacting relationships, work, and education. This has led to increased stress, anxiety, and depression, along with altered sleep patterns and eating behaviors. Quarantine and isolation have worsened mental health, especially in children and the elderly, due to the loss of activities and physical contact. Sleep disorders and negative dreams perpetuate poor sleep q...
Bilateral breast cancer and the influence of body mass index in clinicopatholog...
Luís, Carla; Fernandes, Rute; Dias, João; Pereira, Deolinda; Firmino-Machado, João; Baylina, Pilar; Fernandes, Rúben; Soares, RaquelBreast cancer (BC) and obesity are two closely associated pathologies with increasing incidence and mortality rates. Bilateral Breast Cancer (BBC) displays a low incidence rate within BC and obesity represents a major risk factor. The aim of this study is to analyzed BBC clinicopathological features distribution and determine the potential influence of obesity in BBC in these same features and overall survival....
Uma revisão sistemática sobre biomarcadores pré-diabéticos
Luís, Carla; Pilar, Baylina; Raquel, Soares; Ruben, Fernandes; BAYLINA MACHADO, PILARNo desenvolvimento fisiopatológico da diabetes tipo 2 (DM2) ocorrem variados desequilíbrios metabólicos. Há evidências crescentes de que a disfunção metabólica precede em muito as manifestações clínicas, sendo a pré-diabetes a condição determinante. A modulação da pré-diabetes com intervenções no estilo de vida pode diminuir o risco de desenvolver DM2 em 40 a 70%. O principal problema associado à pré-diabetes é...
Exploring the anti-cancer properties of pomegranate peel aqueous extract
Luís, Carla; Sousa, André P.; Costa, Raquel; Maduro, Ana T.; Pais, Patrick J.; Sá, Sara; Gestoso, Álvaro; Fernandes, Flávia; Jerónimo, ElianaThe objective of this work is to evaluate the influence of pomegranate peel extract (PPE) in the behavior of breast cell lines (epithelial and tumor type) and related oxidative metabolism. Fruitbased functional foods have been the target of increasing scientific research for their physiological and pathophysiological properties. Pomegranate (Punica granatum) is a suitable example with both prophylactic and medi...