2 documents found, page 1 of 1
Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomark...
Marques, V; Afonso, MB; Bierig, N; Duarte-Ramos, F; Santos-Laso, Á; Jimenez-Agüero, R; Eizaguirre, E; Bujanda, L; Pareja, MJ; Luís, R; Costa, ABackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 seru...
High-throughput sequencing identifies 3 novel susceptibility genes for heredita...
Campos, C; Fragoso, S; Luís, R; Pinto, F; Brito, C; Esteves, S; Pataco, M; Santos, S; Machado, P; Vicente, JB; Rosa, JC; Cavaco, BM; Moura, C; Pojo, MCutaneous melanoma is one of the most aggressive human cancers due to its high invasiveness. Germline mutations in high-risk melanoma susceptibility genes have been associated with development hereditary melanoma; however, most genetic culprits remain elusive. To unravel novel susceptibility genes for hereditary melanoma, we performed whole exome sequencing (WES) on eight patients with multiple primary melanoma...