13 documents found, page 1 of 2
Internal carotid artery rupture during endovascular thrombectomy in patients wi...
Lopes, Catarina; Lucas Neto, LiaEndovascular thrombectomy in patients with tandem occlusions can rarely result in the rupture of the internal carotid artery, leading to subarachnoid haemorrhage and death. However, this complication and its causes are rarely reported and discussed in the literature. We describe two cases of internal carotid artery rupture during endovascular thrombectomy in patients with tandem occlusion. It is hypothesised th...
Advances in cerebral venous thrombosis
de Sousa, Diana Aguiar; Lucas Neto, LiaCerebral venous thrombosis (CVT) is a less common form of stroke, predominantly affecting children and young adults. This review synthesizes recent advances in our understanding, diagnostic approaches, and management of patients with CVT, mostly drawing on data from international cohorts and clinical trials.
The role of optic nerve sheath ultrasonography in increased intracranial pressu...
Berhanu, David; Cardoso Ferreira, Joana; Pinto, Luis; de Sousa, Diana Aguiar; Lucas Neto, Lia; Tavares Ferreira, JoanaObjectives: To review the optimal diagnostic cut-off of ultrasonographic optic nerve sheath diameter (ONSD) in the diagnosis of increased intracranial pressure (IICP). Methods: A systematic search was conducted of available studies assessing the use of ONSD ultrasonography in patients with suspected IICP. Meta-analysis of diagnostic accuracy of ultrasonographic ONSD was performed using a bivariate model of rand...
Burnout and dropout intention in medical students: the protective role of acade...
Abreu Alves, Sara; Sinval, Jorge; Lucas Neto, Lia; Marôco, João; Ferreira, António Gonçalves; Oliveira, PedroIntroduction: The influence of burnout, academic engagement, and their interaction in dropout intention among medical students should be further studied. Current research shows its consequences are relevant, however, there is little understanding on burnout and academic engagement moderation in dropout intention. The current study tested a model that relates the effects of coping strategies, social support sati...
Matrix Metalloproteinase-9 levels are associated with brain lesion and persiste...
de Sousa, Diana Aguiar; Pereira Santos, Maria Conceição; Serra-Caetano, Ana; Lucas Neto, Lia; Sousa, Ana Luísa; Gabriel, Denis; Correia, ManuelBackground: Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood-brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations...
Recanalization after cerebral venous thrombosis : a randomized controlled trial...
Ferro, José; Bendszus, Martin; Jansen, Olav; Coutinho, Jonathan M; Dentali, Francesco; Kobayashi, Adam; de Sousa, Diana Aguiar; Lucas Neto, LiaBackground: The effect of different anticoagulants on recanalization after cerebral venous thrombosis has not been studied in a randomized controlled trial. Methods: RE-SPECT CVT (ClinicalTrials.gov number: NCT02913326) was a Phase III, prospective, randomized, parallel-group, open-label, multicenter, exploratory trial with blinded endpoint adjudication. Acute cerebral venous thrombosis patients were allocated ...
Blood biomarkers associated with inflammation predict poor prognosis in cerebra...
de Sousa, Diana Aguiar; Pereira Santos, M. C.; Serra-Caetano, Ana; Lucas Neto, Lia; Sousa, A. L.; Gabriel, D.; Correia, M.; Gil-Gouveia, RaquelBackground and purpose: Experimental studies suggest inflammation can contribute to blood barrier disruption and brain injury in cerebral venous thrombosis (CVT). We aimed to determine whether blood biomarkers of inflammation were associated with the evolution of brain lesions, persistent venous occlusion or functional outcome in patients with CVT. Methods: Pathophysiology of Venous Infarction-Prediction of Inf...
A randomized controlled preclinical trial on 3 interposal temporomandibular joi...
Ângelo, David; Wang, Yadong; Morouço, Pedro; Monje, Florencio; Mónico, Lisete; González‐Garcia, Raúl; Moura, Carla; Alves, Nuno; Sanz, David; Gao, JinThe effort to develop an effective and safe temporomandibular joint (TMJ) disc substitute has been one of the mainstreams of tissue engineering. Biodegradable customized scaffolds could approach safety and effectiveness to regenerate a new autologous disc, rather than using non-biodegradable materials. However, it is still technically challenging to mimic the biomechanical properties of the native disc with bio...
Headache at the chronic stage of ischemic stroke
Carvalho Dias, Mariana; Martins, Teresa; Basílio, Gonçalo; Lucas Neto, Lia; Caeiro, Lara; Ferro, José; Verdelho, AnaBackground.—Headache in ischemic stroke survivors after the acute stage is incompletely described. Objective.—We aimed to prospectively describe the characteristics of headache and the predictors of headache at the chronic stage after ischemic stroke. Methods.—We conducted a prospective observational cohort study including 102 acute ischemic stroke patients admitted to a Stroke Unit. Patients were interviewed a...
Effects of bilateral discectomy and bilateral discopexy on black merino sheep r...
Ângelo, David; Gil, Florencio Monje; González-García, Raúl; Mónico, Lisete; Sousa, Rita; Lucas Neto, Lia; Caldeira, Inês; Moura, CarlaThe temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS - phase 1, investigated the effects of bilateral discectomy and discopexy in sheep mastication and rumination.