5 documents found, page 1 of 1
Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases Fos prot...
Nascimento, Simone de Souza; Araujo, Adriano Antunes de Souza; Brito, Renan Guedes de; Serafini, Mairim Russo; Menezes, Paula dos PassosO. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every da...
Absorption levels and morphological features of fetal organs in wistar rats tre...
Bomfim, Kátia Michelle dos Anjos; Garcia, Carlos Alexandre Borges; Reis, Francisco Prado; Palmeira, José Arnaldo Vasconcelos; Scher, RicardoLead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this...
Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory...
Quintans, Jullyana S.S.; Barreto, Rosana S.S.; Lucca Júnior, Waldecy de; Villarreal, Cristiane F.; Kaneto, Carla M.; Soares, Milena B.P.Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as ‘sisal’, and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the OPEN ACCESSMolecules 2014, 19 8304 antihyperalgesic profile of HA i...
Involvement of cerebral nervous system areas and cytokines on antihyperalgesic ...
Melo, M.S.; Brito, R.G.; Santos, P.L.; Nogueira, P.C.L.; Moraes, V.R.S.; Matos, M.C.P.; Ferro, J.N.S.; Barreto, E.O.; Lucca Júnior, Waldecy deKielmeyera rugosa is a medicinal plant known in Northeastern Brazil as ‘pau-santo’, and it is used in the treatment of several tropical diseases such as malaria, schistosomiasis, and leishmaniasis. We evaluated antihyperalgesic and anti-inflammatory activities of methanol stem extract of K. rugosa (MEKR) in mice. The mechanical hyperalgesia induced by carrageenan and tumor necrosis factor-alpha (TNF-α), prostag...
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine:...
Quintans-Júnior, Lucindo José; Silva, Davi Antas; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Siqueira, Rosana de SouzaWe investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the...