2 documents found, page 1 of 1
Preparation, characterization, and pharmacological activity of Cymbopogon winte...
Santos, Priscila Laíse dos; Araujo, Adriano Antunes de Souza; Quintans, Jullyana de Souza Siqueira; Brito, Renan Guedes de; Serafini, Mairim RussoThis study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG...
Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases fos prot...
Nascimento, Simone de Souza; Araujo, Adriano Antunes de Souza; Brito, Renan Guedes de; Serafini, Mairim Russo; Menezes, Paula dos PassosO. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every da...