5 documents found, page 1 of 1
Curcumin reversion of neurochemical and immunohistochemical alterations in brai...
Lucetti, Elaine Cristina Pereira; Lucetti, Daniel Luna; Ribeiro, Ana Elisa da Silva; Moura, Rafael Barbosa de; Sampaio, Thayga Maria AraújoStroke is one leading cause of mortality and morbidity worldwide where free radicals production and inflammation play important roles. Curcumin, a curcuminoid from Curcuma longa presents several biological properties and is a potent anti-inflammatory and antioxidant agent. The objectives were to study the neuroprotective effects of curcumin on ischemic pups from mothers treated with this drug (25, 50 or 100 mg/...
Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the P...
Correia, Alyne Oliveira; Cruz, Abílio Augusto Pimentel; Aquino, Arôdo Tenório Ribeiro de; Diniz, Joanisson Rubens GomesPiperine (PIP), an alkaloid from the Piper genus plants, presents biological properties, including potent anti-inflammatory actions. Since neuroinflammation plays a key role in Parkinson's disease (PD), the objectives were to evaluate the neuroprotective activity of PIP in a model of PD. Male Wistar rats were divided as: sham-operated (SO), untreated 6-OHDA (lesioned in the right striatum) and 6-OHDA lesioned a...
Lectin isolated from Brazilian seeds of velvet bean ( Mucuna pruriens (L) DC.) ...
Lacerda, Rodrigo Rodrigues e; Moreira, Italo Cordeiro; Nascimento, Jader Sabino Jacó do; Lacerda, Ana Carenina Sampaio de; Cabral, Natasha LucenaLectins are proteins present in all living beings capable of interacting specifically and reversibly to carbohydrates or glycoconjugates form. They stand out in this family of lectins legumes, which are of special scientific interest because they have differen t biological functions. This study investigated the presence of a lectin in Brazilian seeds of Mucuna , proceeding with their isolation and evaluation of...
Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and anti...
Nobre, Maria Elizabeth Pereira; Correia, Alyne Oliveira; Borges, Marília de Brito; Sampaio, Thayga Maria Araújo; Chakraborty, Solon ArcoverdeIn the present study, we evaluated omega-3 polyunsaturated fatty acid (PUFA) (consisting of 20:5n-3 and 22:6n-3) properties on inflammation and nociception. Among the in vivo tests, writhing, formalin, and hot plate tests were conducted in mice, and carrageenan-induced paw edema, peritonitis, and Hargreaves tests were performed in rats. Following the carrageenaninduced edema, immunohistochemistry for tumor necr...
Avaliação das atividades antiinflamatória e antinociceptiva do acetato de lupeo...
Lucetti, Daniel LunaThe lupeol acetate (FAL), isolated from the latex extracted of the stem of Himatanthus drasticus (APOCYNCEAE) is chemically classified as a pentacyclic triterpene belonging to the lupane class, was evaluated in nociception and inflammation models. In the writhing test induced by acetic acid (10 ml/kg, i.p.) in mice, FAL (50 and 100 mg/kg, i.p.) significantly reduced the number of writhing in 56 and 61%, respect...