2 documents found, page 1 of 1
Amifostine reduces inflammation and protects against 5-fluorouracil-induced ora...
Barbosa, Sabrina Carneiro Melo; Pereira, Venúcia B.M.; Wong, Deysi V.T.; Santana, Ana P.M.; Lucetti, Larisse T.; Carvalho, Lucas L.Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) andradiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable.Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy andchemotherapy-associated xerostomia. Th...
Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus ...
Nicolau, Lucas Antonio Duarte; Carvalho, Nathalia S.; Pacífico, Dvison M.; Lucetti, Larisse T.; Aragão, Karoline Sabóia; Véras, Leiz M.C.Objective This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. Methods Initially, rats were pretreated with 0.5% carboxymethylcellulose (vehicle) or EPI (3, 10 and 30 mg/kg, p.o. or i.p., groups 3–5, respectively) twice daily, for 2 days. After 1 h, NAP (80 mg/kg, p.o.) was given. The control group r...