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Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors...
Acúrcio, Rita C; Pozzi, Sabina; Carreira, Barbara; Pojo, Marta; Gómez-Cebrián, Nuria; Casimiro, Sandra; Fernandes, Adelaide; Barateiro, AndreiaBackground: Inhibiting programmed cell death protein 1 (PD-1) or PD-ligand 1 (PD-L1) has shown exciting clinical outcomes in diverse human cancers. So far, only monoclonal antibodies are approved as PD-1/PD-L1 inhibitors. While significant clinical outcomes are observed on patients who respond to these therapeutics, a large proportion of the patients do not benefit from the currently available immune checkpoint...
Discovery and development of new small-molecule immune system modulators
Acúrcio, Rita CModulation of immune modulatory pathways has emerged as one of the most successful and explored approaches for cancer immunotherapy. Current therapeutics include monoclonal antibodies, which have shown impressive clinical outcomes in the treatment of several types of tumors. However, low response rate, patient acquired resistance and induction of severe immune-related adverse effects represent critical drawback...