87 documents found, page 1 of 9
Prevascularized spongy-like hydrogels maintain their angiogenic potential after...
Ribeiro, Sara Cristina Freitas; Moreira, H.; da Silva, Lucília Pereira; Noro, Jennifer Martins; Sampaio-Marques, B.; Ludovico, Paula; Jarnalo, M.The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization being a critical factor for in vivo survival and integration of tissue engineering products. Concurrently, a different challenge hindering the clinical impleme...
Medicina: ciência, educação e inovação ao “serviço da vida humana”
Correia-Pinto, Jorge; Leite-Almeida, Hugo; Palha, Joana Almeida; Ludovico, Paula; Morgado, Pedro; Leão, Cecília[Excerto] Escola, desde sempre, se apresentou como um espaço de liberdade e diversidade que fomenta a curiosidade e a produção de conhecimento, conferindo autonomia científica, técnica e profissional a todos os que nela se formam e diferenciam. Esta Escola representa, a todos os níveis, um marco inovador na formação médica, primando pela excelência, não só nos eixos de atividade tradicionais – pedagógico, cient...
The yeast protein kinase Sch9 functions as a central nutrient-responsive hub th...
Caligaris, Marco; Marques, Maria Belém Sousa Sampaio; Hatakeyama, Riko; Pillet, Benjamin; Ludovico, Paula; De Virgilio, Claudio; Winderickx, JorisYeast cells are equipped with different nutrient signaling pathways that enable them to sense the availability of various nutrients and adjust metabolism and growth accordingly. These pathways are part of an intricate network since most of them are cross-regulated and subject to feedback regulation at different levels. In yeast, a central role is played by Sch9, a protein kinase that functions as a proximal eff...
Polymorphisms within autophagy-related genes as susceptibility biomarkers for m...
Clavero, Esther; Sanchez-Maldonado, José Manuel; Macauda, Angelica; Ter Horst, Rob; Marques, Maria Belém Sousa Sampaio; Jurczyszyn, ArturMultiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promot...
Current and emerging techniques for diagnosis and MRD detection in AML: a compr...
Teixeira, Alexandra; Carreira, Luís; Abalde-Cela, Sara; Sampaio-Marques, Belém; Areias, Anabela C.; Ludovico, Paula; Diéguez, LorenaAcute myeloid leukemia (AML) comprises a group of hematologic neoplasms characterized by abnormal differentiation and proliferation of myeloid progenitor cells. AML is associated with poor outcome due to the lack of efficient therapies and early diagnostic tools. The current gold standard diagnostic tools are based on bone marrow biopsy. These biopsies, apart from being very invasive, painful, and costly, have ...
Effects of intermittent fasting on regulation of metabolic homeostasis: a syste...
Silva, Ana Inês; Direito, Manuel; Pinto-Ribeiro, Filipa; Ludovico, Paula; Marques, Maria Belém Sousa SampaioIntermittent fasting (IF) is an emerging dietetic intervention that has been associated with improved metabolic parameters. Nowadays, the most common IF protocols are Alternate-Day Fasting (ADF) and Time-Restricted Fasting (TRF), but in this review and meta-analysis we have also considered Religious Fasting (RF), which is similar to TRF but against the circadian rhythm. The available studies usually include the...
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erin...
Tripodi, Farida; Falletta, Ermelinda; Leri, Manuela; Angeloni, Cristina; Beghelli, Daniela; Giusti, Laura; Milanesi, Riccardo; Sampaio-Marques, BelémNutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders. Among these, Parkinson’s disease (PD) affects 10 million people worldwide and is associated with α-synuclein mi...
Polymorphisms within autophagy-related genes influence the risk of developing c...
Sainz, Juan; García-Verdejo, Francisco José; Martínez-Bueno, Manuel; Kumar, Abhishek; Sánchez-Maldonado, José Manuel; Díez-Villanueva, AnnaThe role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data from four independent Europe...
Functional genetic variants in ATG10 are associated with acute myeloid leukemia
Castro, Isabel; Marques, Maria Belém Sousa Sampaio; Areias, Anabela Cepa; Sousa, Hugo; Fernandes, Ângela; Sanchez-Maldonado, José ManuelAcute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic reprogramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the <i>ATG10</i> gene, central for the autophagosome formation....
Unravelling the anticancer potential of functionalized chromeno[2,3-b ] pyridin...
Oliveira-Pinto, Sofia; Pontes, Olivia; Lopes, Diogo; Marques, Maria Belém Sousa Sampaio; Costa, Marta D.; Carvalho, Luisa; Goncalves, Celine S.A selection of new chromeno[2,3-b]pyridines was prepared from chromenylacrylonitriles and N-substituted piperazines, using a novel and efficient synthetic procedure. The compounds were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds showed higher activity towards the luminal b...