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Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0...

Espay, Alberto J; Stocchi, Fabrizio; Pahwa, Rajesh; Albanese, Alberto; Ellenbogen, Aaron; Ferreira, Joaquim J; Giladi, Nir; Gurevich, Tanya

Background: Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion strategies might provide more consistent drug delivery and fewer motor fluctuations. We aimed to assess the safety and efficacy of a continuous 24 h/day subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) compared with oral immediate-re...

Date: 2024   |   Origin: Repositório da Universidade de Lisboa
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