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Inhibitory effect of a Brazilian marine brown alga Spatoglossum schröederi on b...
Domingos,Thaisa Francielle Souza; Ortiz-Ramírez,Fredy A.; Villaça,Roberto C.; Cavalcanti,Diana N.; Sanchez,Eladio F.; Teixeira,Valéria L.The ability of crude extracts of the brown seaweed Spatoglossum schröederi to counteract some of the biological activities of Lachesis muta snake venom was evaluated. In vitro assays showed that only the extract of S. schröederi prepared in ethyl acetate was able to inhibit the clotting of fibrinogen induced by L. muta venom. On the other hand, all extracts were able to inhibit partially the hemolysis caused by...
Marine natural seaweed products as potential antiviral drugs against Bovine vir...
Pinto,Ana Maria Viana; Leite,José Paulo G.; Ferreira,Wilton J.; Cavalcanti,Diana N.; Villaça,Roberto C.; Giongo,Viveca; Teixeira,Valéria L.Bovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the world. The purpose of this study was to evaluate the in vitro cytotoxic effect and antiviral properties of several marine natural products obtained from seaweeds: the indole alkaloid caulerpin (CAV, 1) and three diterpenes: 6-hydroxydichotoma-3,14-diene-...
Caulerpin as a potential antiviral drug against herpes simplex virus type 1
Macedo,Nathália Regina Porto Vieira; Ribeiro,Michele S.; Villaça,Roberto C.; Ferreira,Wilton; Pinto,Ana Maria; Teixeira,Valéria L.; Cirne-Santos,ClaudioAbout 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV patients. In addition to resistance, the drugs also have toxicity, particularly when administration is prolonged. The study of new molecules isolated from green algae w...