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Inhibition of CXCR2 Plays a Pivotal Role in Re-Sensitizing Ovarian Cancer to Ci...
Henriques, TB; Santos, DZ; Guimarães, IDS; Tessarollo, NG; Lyra-Junior, PCM; Mesquita, P; Pádua, D; Amaral, AL; Cavadas, B; Pereira, L; Silva, IVcDNA microarray data conducted by our group revealed overexpression of CXCL2 and CXCL8 in ovarian cancer (OC) microenvironment. Herein, we have proven that the chemokine receptor, CXCR2, is a pivotal molecule in re-sensitizing OC to cisplatin, and its inhibition decreases cell proliferation, viability, tumor size in cisplatinresistant cells, as well as reversed the overexpression of mesenchymal epithelium trans...
Date: 2021
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Origin: Repositório Aberto da Universidade do Porto