16 documents found, page 1 of 2
Shedding light on the african enigma: In vitro testing of homo sapiens-helicoba...
Cavadas, B; Leite, M; Pedro, N; Magalhães, AC; Melo, J; Correia, M; Máximo, V; Camacho, R; Fonseca, NA; Figueiredo, C; Pereira, LThe continuous characterization of genome-wide diversity in population and case- cohort samples, allied to the development of new algorithms, are shedding light on host ancestry impact and selection events on various infectious diseases. Especially interesting are the longstanding associations between humans and certain bacteria, such as the case of Helicobacter pylori, which could have been strong drivers of a...
Proteomics analysis of gastric cancer patients with diabetes mellitus
Osorio, H; Silva, C; Ferreira, M; Gullo, I; Máximo, V; Barros, R; Mendonça, F; Oliveira, C; Carneiro, FProteomics is a powerful approach to study the molecular mechanisms of cancer. In this study, we aim to characterize the proteomic profile of gastric cancer (GC) in patients with diabetes mellitus (DM) type 2. Forty GC tissue samples including 19 cases from diabetic patients and 21 cases from individuals without diabetes (control group) were selected for the proteomics analysis. Gastric tissues were processed f...
Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical App...
Canberk, S; Lima, AR; Pinto, M; Soares, P; Máximo, VIt has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they pl...
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration T...
Canberk, S; Lima, AR; Pinto, M; Máximo, VThe awareness of epigenetic alterations leading to neoplasia attracted the attention of researchers toward its potential use in the management of cancer, from diagnosis to prognosis and prediction of response to therapies. Our group has focused its attention on the epigenomics of thyroid neoplasms. Although most of the epigenetic studies have been applied on histological samples, the fact is that cytology, thro...
Clinical validation of a urine test (uromonitor-V2(®)) for the surveillance of ...
Sieverink, CA; Batista, R; Prazeres, H; Vinagre, J; Sampaio, C; Leão, RR; Máximo, V; Alfred Witjes, J; Soares, PThe costly and burdensome nature of the current follow-up methods in non-muscle-invasive bladder cancer (NMIBC) drives the development of new methods that may alternate with regular cystoscopy and urine cytology. The Uromonitor-V2® is a new urine-based assay in the detection of hotspot mutations in three genes (TERT, FGFR3, and KRAS) for evaluation of disease recurrence. The aim of this study was to investigate...
Biomarkers for bladder cancer diagnosis and surveillance: A comprehensive review
Batista, R; Vinagre, N; Meireles, S; Vinagre, J; Prazeres, H; Leão, R; Máximo, V; Soares, PBladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by in...
TERT promoter mutation as a potential predictive biomarker in BCG-treated bladd...
Batista, R; Lima, L; Vinagre, J; Pinto, V; Lyra, J; Máximo, V; Santos, L; Soares, PTelomerase reverse transcriptase gene promoter (TERTp) mutations are recognized as one of the most frequent genetic events in bladder cancer (BC). No studies have focused on the relevance of TERTp mutations in the specific group of tumors treated with Bacillus Calmette–Guérin (BCG) intravesical therapy. Methods — 125 non muscle invasive BC treated with BCG therapy (BCG-NMIBC) were screened for TERTp mutations, ...
Evaluation of the role of mitochondria in the non-targeted effects of ionizing ...
Miranda, S; Correia, M; Dias, AG; Pestana, A; Soares, P; Nunes, J; Lima, J; Máximo, V; Boaventura, PRadiobiology is moving towards a better understanding of the intercellular signaling that occurs upon radiation and how its effects relate to the dose applied. The mitochondrial role in orchestrating this biological response needs to be further explored. Cybrids (cytoplasmic hybrids) are useful cell models for studying the involvement of mitochondria in cellular processes. In the present study we used cybrid ce...
Prostate cancer proliferation is affected by the subcellular localization of MC...
Valença, I; Ferreira, AR; Correia, M; Kühl, S; Roermund, C; Waterham, HR; Máximo, V; Islinger, M; Ribeiro, DReprogramming of lipid metabolism directly contributes to malignant transformation and progression. The increased uptake of circulating lipids, the transfer of fatty acids from stromal adipocytes to cancer cells, the de novo fatty acid synthesis, and the fatty acid oxidation support the central role of lipids in many cancers, including prostate cancer (PCa). Fatty acid ß-oxidation is the dominant bioenergetic p...
Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence ...
Batista, R; Vinagre, J; Prazeres, H; Sampaio, C; Peralta, P; Conceição, P; Sismeiro, A; Leão, R; Gomes, A; Furriel, F; Oliveira, C; Torres, JNBladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70–75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an i...