8 documents found, page 1 of 1
Study of the relevance of antioxidant enzymes in thyroid cancer
Freitas, Sílvia; Peixoto, Joana; Máximo, Valdemar; Soares, PaulaThyroid cancer(TC) is the most common endocrine malignancy, arising from follicular and parafollicular cells. Oxidative stress, caused by excess reactive oxygen species(ROS) and metabolites, influences TC development and progression, as the thyroid is highly exposed to ROS. The redox balance is maintained by antioxidant enzymes (SOD, GPX) and non-enzymatic antioxidants, which limit ROS formation and detoxify me...
Targeting mitochondrial TERT to overcome therapeutic resistance
Chantre, Ana; Correia, Marcelo; Soares, Paula; Máximo, Valdemar; Lima, Raquel T.Reactivation of telomerase is a common process in most human tumours [1, 2], usually due to reexpression of its catalytic subunit, the telomerase reverse transcriptase (TERT), contributing to cell immortalization [3]. In thyroid cancer (TC), it was demonstrated that TERT reactivation is often associated with distant metastases, therapy resistance and shorter survival rates of patients [4], however TERTs’ canoni...
Performance of the Bethesda system for reporting thyroid cytology in multi-inst...
Canberk, Sule; Barroca, Helena; Girão, Inês; Aydın, Ozlem; Uguz, Aysun; Erdogan, Kıvılcım; Tastekin, Ebru; Bongiovanni, Massimo; Soares, PaulaBackground: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk o...
Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review
Batista, Rui; Vinagre, Nuno; Meireles, Sara; Vinagre, João; Prazeres, Hugo; Leão, Ricardo; Máximo, Valdemar; Soares, PaulaBladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by in...
Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence ...
Batista, Rui; Vinagre, João; Prazeres, Hugo; Sampaio, Cristina; Peralta, Pedro; Conceição, Paulo; Sismeiro, Amílcar; Leão, Ricardo; Gomes, AndreiaBladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70-75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an i...
Dynamin-Related Protein 1 at the Crossroads of Cancer
Lima, Ana Rita; Santos, Liliana; Correia, Marcelo; Soares, Paula; Sobrinho-Simões, Manuel; Melo, Miguel; Máximo, ValdemarMitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involve mitochondrial dynamics (fission and fusion), which occur in normal cells as well as in cells ...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...