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Plasmodium Merozoite TRAP family protein is essential for vacuole membrane disr...

Ménard, Robert

Date: 2016   |   Origin: Oasisbr
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Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity

Briquet, Sylvie; Lawson-Hogban, Nadou; Boisson, Bertrand; Soares, Miguel P; Péronet, Roger; Smith, Leanna; Ménard, Robert; Huerre, Michel

Eukaryotic high-mobility-group-box (HMGB) proteins are nuclear factors involved in chromatin remodeling and transcription regulation. When released into the extracellular milieu, HMGB1 acts as a proinflammatory cytokine that plays a central role in the pathogenesis of several immune-mediated inflammatory diseases. We found that the Plasmodium genome encodes two genuine HMGB factors, Plasmodium HMGB1 and HMGB2, ...

Date: 2015   |   Origin: ARCA - Access to Research and Communication Annals
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