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First outbreak of NDM-1-producing Klebsiella pneumoniae ST11 in a Portuguese ho...

Mendes, Gabriel; Ramalho, João Francisco; Duarte, Aida; Pedrosa, Adriana; Silva, Ana Cristina; Méndez, Lucía; Caneiras, Catia

New Delhi metallo-β-lactamase (NDM) carbapenemase has been considered a global threat due to its worldwide widespread in recent years. In Portugal, a very low number of infections with NDM-producing Enterobacterales has been reported. A total of 52 strains from 40 patients and 1 environmental sample isolated during COVID-19 pandemic were included in this study. Wholegenome sequencing (WGS) was performed on 20 c...


First outbreak of NDM-1-producing Klebsiella pneumoniae ST11 in a Portuguese ho...

Mendes, Gabriel; Ramalho, João F.; Duarte, Aida; Pedrosa, Adriana; Silva, Ana Cristina; Méndez, Lucía; Caneiras, Cátia

New Delhi metallo-β-lactamase (NDM) carbapenemase has been considered a global threat due to its worldwide widespread in recent years. In Portugal, a very low number of infections with NDM-producing Enterobacterales has been reported. A total of 52 strains from 40 patients and 1 environmental sample isolated during COVID-19 pandemic were included in this study. Wholegenome sequencing (WGS) was performed on 20 c...


Hafnia alvei Pneumonia: a rare cause of infection in a patient with COVID-19

Méndez, Lucía; Ferreira, Jorge; Caneiras, Catia

Herein, we describe a case report of a critically ill patient, a 48-year-old man without comorbidities admitted to the hospital with a serious type 1 (hypoxemic) respiratory insufficiency and confirmed diagnosis of COVID-19. After 5 days with invasive mechanical ventilation, the patient developed a bacterial co-infection, namely a pneumonia by Hafnia alvei, requiring the last line of respiratory support: extrac...


Epidemiological characterization and the impact of healthcare-associated pneumo...

Méndez, Lucía; Castro, Pedro; Ferreira, Jorge; Caneiras, Catia

Pneumonia is one of the main causes of hospitalization and mortality. It's the fourth leading cause of death worldwide. Healthcare-associated infections are the most frequent complication of healthcare and affect hundreds of millions of patients around the world, although the actual number of patients affected is unknown due to the difficulty of reliable data. The main goal of this manuscript is to describe the...


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