2 documents found, page 1 of 1
PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain...
Szecskó, Anikó; Mészáros, Mária; Simões, Beatriz T.; Cavaco, Marco; Chaparro, Catarina; Porkoláb, Gergő; Castanho, Miguel A. R. B.; Deli, Mária A.Background: Nanocarriers targeting the blood-brain barrier (BBB) are promising drug delivery systems to enhance the penetration of therapeutic molecules into the brain. Immunotherapy, particularly monoclonal antibodies designed to bind amyloid-beta peptides have become a promising strategy for Alzheimer's disease, but ensuring efficacy and safety is challenging and crucial for these therapies. Our aim was to de...
Lidocaine turns the surface charge of biological membranes more positive and ch...
Santa-Maria, Ana R.; Walter, Fruzsina R.; Valkai, Sándor; Brás, Ana Rita; Mészáros, Mária; Kincses, András; Klepe, Adrián; Gaspar, DianaThe surface charge of brain endothelial cells forming the blood-brain barrier (BBB) is highly negative due to phospholipids in the plasma membrane and the glycocalyx. This negative charge is an important element of the defense systems of the BBB. Lidocaine, a cationic and lipophilic molecule which has anaesthetic and antiarrhytmic properties, exerts its actions by interacting with lipid membranes. Lidocaine whe...