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A2A adenosine receptor deletion is protective in a mouse model of Tauopathy
Laurent, C.; Burnouf, S.; Ferry, B.; Batalha, Vânia; Coelho, Joana E; Baqi, Y.; Malik, E.; Mariciniak, E.; Parrot, S.; Van der Jeugd, A.; Faivre, E.Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models. However, the impact of selective A2AR blockade on the progressive development of AD-related lesions and associated memory impairments has not been investigated. In the present study, we removed t...
Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits a...
Batalha, V. L.; Pêgo, José M.; Fontinha, B. M.; Costenla, A. R.; Valadas, J. S.; Baqi, Y.; Radjainia, H.; Müller, C. E.; Sebastião, A. M.; Lopes, L. V.Maternal separation (MS) is an early life stress model that induces permanent changes in the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial working memory. There are compelling evidences for a role of hippocampal adenosine A(2A) receptors in stress-induced modifications related to cognition, thus opening a potential window for therapeutic intervention. Here, we submitted ...