6 documents found, page 1 of 1
Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing...
Gao, Qiang; Gao, Yunxia; Cao, Yingui; Xu, Haiting; Ma, Ya; Zu, Menghang; Yang, Qiang; Yang, Kun; Zhu, Zhenhua; Liu, Chao; Shi, X. X.; Reis, R. L.The clinical application of CRISPR-Cas9 remains limited by delivery challenges, particularly for oral administration. Lysine-specific demethylase 1 (Lsd1) plays a key role in colonic inflammation and tumorigenesis. Here, we developed an oral genome-editing platform (TPGS-RNP@LNP), where Lsd1-targeting ribonucleoproteins (RNPs) were encapsulated in mulberry leaf lipid nanoparticles (LNPs) and formulated with d-α...
An oral nanomedicine elicits in situ vaccination effect against colorectal cancer
Zu, Menghang; Ma, Ya; Zhang, Jun; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Pan, Guoqing; Reis, R. L.; Kundu, Subhas C; Liu, Jinyao; Xiao, BoOral administration is the most preferred approach for treating colon diseases, and in situ vaccination has emerged as a promising cancer therapeutic strategy. However, the lack of effective drug delivery platforms hampered the application of in situ vaccination strategy in oral treatment of colorectal cancer (CRC). Here, we construct an oral coreâ shell nanomedicine by preparing a silk fibroin-based dual s...
Transient mild photothermia improves therapeutic performance of oral nanomedici...
Ma, Ya; Gou, Shuangquan; Zhu, Zhenhua; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Si,Tieyan; Xu, Cheng; Ru, Jinlong; Shi, Xiaoxiao; Reis, R. L.The treatment outcomes of oral medications against ulcerative colitis (UC) have long been restricted by low drug accumulation in the colitis mucosa and subsequent unsatisfactory therapeutic efficacy. Here, high-performance pluronic F127 (P127)-modified gold shell (AuS)-polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near-infrared irradiation, the resultant P127-AuS@CURs generat...
Mulberry leaf lipid nanoparticles: a naturally targeted CRISPR/Cas9 oral delive...
Ma, Lingli; Ma, Ya; Gao, Qiang; Liu, Shengsheng; Zhu, Zhenhua; Shi, Xiaoxiao; Dai, Fangyin; Reis, R. L.; Kundu, Subhas C; Cai, Kaiyong; Xiao, BoOral treatment of colon diseases with the CRISPR/Cas9 system has been hampered by the lack of a safe and efficient delivery platform. Overexpressed CD98 plays a crucial role in the progression of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC). In this study, lipid nanoparticles (LNPs) derived from mulberry leaves are functionalized with Pluronic copolymers and optimized to deliver the CR...
Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted t...
Gao, Qiang; Chen, Nanx; Li, Baoyi; Zu, Menghang; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe clinical application of conventional medications for hepatocellular carcinoma treatment has been severely restricted by their adverse effects and unsatisfactory therapeutic effectiveness. Inspired by the concept of â medicine food homologyâ , we extracted and purified natural exosome-like lipid nanoparticles (LNPs) from black mulberry (Morus nigra L.) leaves. The obtained MLNPs possessed a desirable hydrod...
Mulberry biomass-derived nanomedicines mitigate colitis through improved inflam...
Yang, Wenjing; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Wu, Jiaxue; Xu, Cheng; Sun, Wei; Zhao, Erhu; Wang, Min; Reis, R. L.; Kundu, Subhas C; Shi, XiaoxiaoThe therapeutic outcomes of conventional oral medications against ulcerative colitis (UC) are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment. Herein, a fluorinated pluronic (FP127) was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles (MLNs) loading with resveratrol nanocrystals (RNs). The o...