3 documents found, page 1 of 1
α-Lipoic acid as adjunctive treatment for schizophrenia : an open-label trial
Sanders, Lia Lira Olivier; Menezes, Carlos Eduardo de Souza; Chaves Filho, Adriano José Maia; Viana, Glautemberg de Almeida; Fechine, Francisco VagnaldoPurpose/Background: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. Methods/Procedures: In this pilot investigation, we administered ALA (100 mg/d) for 4...
N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent ...
Okamura, Adriana Mary Nunes Costa; Gomes, Patrícia Xavier L.; Oliveira, Gersilene V. de; Araújo, Fernanda Yvelize R. de; Tomaz, Viviane S.Kindling We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To ...
Preclinical evidences for an antimanic effect of carvedilol
Souza, Greicy Coelho de; Gomes, Julia Ariana de S.; Queiroz, Ana Isabelle de Góis; Araújo, Maíra Morais de; Cavalcante, Lígia MenezesOxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD woul...