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Practical Guidance on the Detection of NTRK Fusions in Sarcomas
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloPublisher Copyright: © 2025 CELOM. All rights reserved.; Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed no...
Identification of biomarkers predictive of metastasis development in early-stag...
Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Casimiro, Sandra; Sobral, Daniel; Grosso, Ana Rita; Abreu, Catarina; Macedo, DanielaPublisher Copyright: © 2023, The Author(s).; Colorectal cancer (CRC) is the third most common cancer and the second most deathly worldwide. It is a very heterogeneous disease that can develop via distinct pathways where metastasis is the primary cause of death. Therefore, it is crucial to understand the molecular mechanisms underlying metastasis. RNA-sequencing is an essential tool used for studying the transcr...
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...
Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, SandraWe thank João Neto and remaining Computational Multi-Omics Lab members at UCIBIO for their helpful comments and suggestions. © 2022. The Author(s).; Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in ...