4 documents found, page 1 of 1
Marcadores sorológicos como parâmetros de risco para o desenvolvimento da hanse...
Macedo, Alexandre Casimiro deAmong the challenges in leprosy, they deserve attention; late diagnosis, involvement in children and limitations of biomarkers. The objective of this study was to investigate the role of serum and salivary markers in leprosy. And, specific: 1) to determine the performance of serological markers in patients with leprosy; 2) to verify the occurrence of active transmission by Mycobacterium leprae between intra- an...
Efeito da revacinação com bcg na detecção de anticorpos ANTI-PGL1 em contatos m...
Aguiar, Edglesy Carneiro; Pinto, Luiz Carlos Albuquerque; Macedo, Alexandre Casimiro de; Nagao-Dias, Aparecida Tiemi; Câmara, Lília Maria CarneiroA vacina BCG é ministrada ao nascer como imunoprofilaxia contra a tuberculose, sendo indicada a revacinação aos contatos de hanseníase, sem sinais e/ou sintomas da doença, e com uma ou nenhuma cicatriz vacinal, variando, no Brasil, a proteção de 20 a 80%. O Brasil tem 96% dos casos novos de hanseníase em ≤ 15 anos das Américas, tornando a faixa etária objeto de estudos para diagnóstico precoce. A pesquisa sorol...
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium lepra...
Macedo, Alexandre Casimiro de; Cunha Júnior, José Evandro; Yaochite, Juliana Navarro Ueda; Tavares, Clodis Maria; Nagao-Dias, Aparecida TiemiConsidering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alago...
Anti-PGL1 salivary IgA/IgM, serum IgG/IgM, and nasal Mycobacterium leprae DNA i...
Cabral, Paula Brito e; Cunha Júnior, José Evandro; Macedo, Alexandre Casimiro de; Gondim, Ana Paula Soares; Pinto, Maria Isabel MoraesObjectives: Leprosy household contacts represent a group at high risk of developing the disease. The aim of this study was to detect Mycobacterium leprae subclinical infection in this group through serological and molecular parameters. Methods: Serum anti-PGL1 IgG/IgM and salivary anti-PGL1 IgA/IgM was investigated using an ELISA, and nasal carriage of M. leprae DNA was detected by PCR, in leprosy household con...