8 documents found, page 1 of 1
Impact of the use of cryoprotectants in the production of freeze-dried soluble ...
Barroso, Livia Alves; Viegas, Cláudia; Stančiauskaitė, Monika; Macedo, Ana S.; Lemos, Iara Lopes; da Costa, Joyce Maria Gomes; Schmiele, MarcioCold brew is a method of coffee extraction that uses low temperature, preserving the volatile compounds of coffee. Freeze-drying allows the preservation of coffee features and nutritional value. The aim of this study was to evaluate the effects of different cryoprotectants in cold brew extracts as a basis for freeze-dried coffee production. Thus, the Coffea arabica extracts and the soluble coffee were character...
Advances in Pancreatic Cancer treatment by Nano-Based drug delivery systems
Viegas, Cláudia; Patrício, Ana B.; Prata, João; Fonseca, Leonor; Macedo, Ana S.; Duarte, Sofia O. D.; Fonte, PedroPancreatic cancer represents one of the most lethal cancer types worldwide, with a 5-year survival rate of less than 5%. Due to the inability to diagnose it promptly and the lack of efficacy of existing treatments, research and development of innovative therapies and new diagnostics are crucial to increase the survival rate and decrease mortality. Nanomedicine has been gaining importance as an innovative approa...
Fusions of a carbohydrate binding module with the small cationic hexapeptide RW...
Barbosa, Mariana; Simões, Hélvio; Pinto, Sandra N.; Macedo, Ana S.; Fonte, Pedro; Prazeres, D.Miguel F.The emergence of antibiotic-resistant bacteria is a critical worldwide healthcare problem. In the specific case of wound care, new and effective alternatives to currently available solutions are urgently needed. Cellulose-based dressings, for example, could be made more attractive if rendered antimicrobial. This work proposes a new strategy to modify cellulose-based materials with the short antimicrobial hexape...
Evaluation of the antitumour and antiproliferative effect of Xanthohumol-Loaded...
Fonseca, Magda; Macedo, Ana S.; Lima, Sofia A. Costa; Reis, Salette; Soares, Raquel; Fonte, PedroCutaneous melanoma is the deadliest type of skin cancer and current treatment is still inadequate, with low patient survival rates. The polyphenol xanthohumol has been shown to inhibit tumourigenesis and metastasization, however its physicochemical properties restrict its application. In this work, we developed PLGA nanoparticles encapsulating xanthohumol and tested its antiproliferative, antitumour, and migrat...
Nanocarrier-mediated topical insulin delivery for wound healing
Macedo, Ana S.; Mendes, Francisca; Filipe, Patrícia; Reis, Salette; Fonte, PedroWound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use...
Novel and revisited approaches in nanoparticle systems for buccal drug delivery
Macedo, Ana S.; Castro, Pedro M.; Roque, Luís; Thomé, Natália G.; Reis, Catarina P.; Pintado, Maria Manuela; Fonte, PedroThe buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptab...
Design and synthesis of novel quinic acid derivatives: in vitro cytotoxicity an...
Murugesan, Akshaya; Holmstedt, Suvi; Brown, Kenna C.; Koivuporras, Alisa; Macedo, Ana S.; Nguyen, Nga; Fonte, Pedro; Rijo, Patricia; Yli-Harja, OlliAim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA-derivatives against glioblastoma is not well established. Methodology & results: Sixteen novel QA-derivatives and QA-16 encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA-16-NPs) were screened for their anti-glioblastoma effect using standard cell and molecular biology methods. ...
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry p...
Marante, Tânia; Viegas, Cláudia Sofia; Duarte, Inês; Macedo, Ana S.; Fonte, PedroThe delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circu...