3 documents found, page 1 of 1
Decorative Chromium Coatings on Polycarbonate Substrate for the Automotive Indu...
Ponte, Filipa; Sharma, Pooja; Figueiredo, Nuno Miguel; Ferreira, Jorge; Carvalho, SandraMetal-coated plastic parts are replacing traditional metallic materials in the automotive industry. Sputtering is an alternative technology that is more environmentally friendly than electrolytic coatings. Most metalized plastic parts are coated with a thin metal layer (~100-200 nm). In this work, the challenge is to achieve thicker films without cracking or without other defects, such as pinholes or pores. Chr...
Estrogens decrease osteoclast number by attenuating mitochondria oxidative phos...
Kim, Ha-Neui; Ponte, Filipa; Nookaew, Intawat; Ucer Ozgurel, Serra; Carvalho, Adriana Marques; Iyer, Srividhya; Warren, Aaron; Aykin-Burns, NukhetLoss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-estradiol (E2) decreased osteoclast number by promoting the apoptosis of early osteoclast progenitors, but not matur...
Fanconi anemia: cytogenetic diagnosis of 40 cases.
Porto, Beatriz; Sousa, Rosa; Ponte, Filipa; Torgal, Ana; Campilho, Fernando; Campos, António; Gonçalves, Cristina; Barbot, JoséFanconi Anemia (FA) is a rare recessive disorder clinically characterized by progressive bone marrow failure, diverse congenital malformations and increased predisposition to cancer. Given the late onset of anemia, relatively to other cytopenias, and the high variability in the phenotype, a correct clinical diagnosis is difficult, and may be delayed or even missed. This fact may be prejudicial to patients, due ...