4 documents found, page 1 of 1
Stress, Spirituality, and Altruism of Brazilian Medical Students during the COV...
Lima Junior, David Nunes de; Aguiar, Ridson Guilherme Parente de; Kubrusly, Bruna Sobreira; Macedo, Danielle S.; Kubrusly, MarcosSpirituality and altruism may be critical coping strategies to minimize emotional pain during period of crisis. Here we aim to investigate how spirituality and altruism are related and whether they influence medical students' levels of stress during the COVID-19 pandemic. Data were collected when most Brazilian states had already been promoting social isolation in response to the COVID-19 pandemic using self-re...
Involvement of the dopaminergic system in the antidepressant-like effect of the...
Abreu, Ticiana Monteiro; Monteiro, Valdécio Silvano; Martins, Ana Beatriz Souza; Teles, Felipe Barros; Rivanor, Renata Line da ConceiçãoThis study aimed at evaluating the antidepressant-like action of the marine alga Solieria filiformis lectin (SfL) and to investigate the participation of the monoaminergic system in this action. For this, male Swiss mice (n=10) were pretreated with intravenous injections (i.v.) of SfL (1, 3 or 9mg/kg) and submitted to open field (OFT), tail suspension (TST), forced swimming (FST), elevated plus-maze (EPMT) and ...
Leptin prevents lipopolysaccharide-induced depressive-like behaviors in mice: i...
Cordeiro, Rafaela Carneiro; Chaves Filho, Adriano José Maia; Medeiros, Camila Dantas; Queiroz, Ana Isabelle de Góis; Maes, Michael; Macedo, Danielle S.Depression is a chronic and recurrent disorder, associated with high morbidity and risk of suicide. Leptin was firstly described as an anti-obesity hormone, but several actions of leptin in CNS have been reported. In fact, leptin regulates dopaminergic neurotransmission in mesolimbic areas and has antidepressant-like properties in stress-based models. In the present study, we investigated, for the first time, p...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...