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Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharid...

Fernandes, Tiago A.; Macedo, Filipa; Cabral, Rafaela G.; Guiu, Telma; Franco, Chris H. J.; Jorge, Paula; Sousa, Ana Catarina; André, Vânia; Cerca, Nuno

This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(6-sdba)]n (1) and [Cu(4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymer films based...


Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharid...

Fernandes, Tiago; Macedo, Filipa; Cabral, Rafaela G.; Guiu, Telma; Franco, Chris H. J.; Jorge, Paula; Sousa, Ana Catarina; Anfré, Vânia; Cerca, Nuno

This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(μ6-sdba)]n (1) and [Cu(μ4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4′-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymerfilms bas...


O método de extração de DNA influencia a taxa de recuperação dos controlos exóg...

Lima, Ângela Martins; França, Ângela Maria Oliveira Sousa; Sousa, Lúcia Filipa Guimarães Vieira; Macedo, Filipa; Cerca, Nuno

Background. O PCR quantitativo, método baseado no princípio da reação em cadeia da polimerase, é um procedimento bem estabelecido e extensivamente usado para a quantificação bacteriana, sobretudo devido à sua sensibilidade, acessibilidade, facilidade de utilização e robustez. Foram por isso estabelecidas diretrizes, há mais de 10 anos, com o propósito de orientar os investigadores a utilizar esta metodologia de...


Assessing recovery rates of distinct exogenous controls for gDNA extraction eff...

Lima, Ângela Martins; Sousa, Lúcia Filipa Guimarães Vieira; Macedo, Filipa; Muzny, Christina A.; Cerca, Nuno

Assessment of genomic DNA (gDNA) extraction efficiency is required for accurate bacterial quantification by qPCR. Exogenous DNA molecules are often added after bacterial cultures are lysed, but before DNA purification steps, to determine extraction efficiency. Herein we found that different exogenous DNA controls have different recovery rates, suggesting distinct DNA extraction efficiencies. Recovery rates are ...


Multiple primary cancers: an overview

Macedo, Filipa; Pinho, Filipa; Saraiva, Nadine; Bonito, Nuno; Pinto, Luísa; Gonçalves, Francisco

The prevalence of patients living after a diagnosis of cancer has increased due to the rising incidence, better treatments and improved survival rate. The risk of further primary cancers might be expected to be rising because of the persisting effects of genetic and behavioural risk factors, long-term side-effects of chemo and radiotherapy, increased diagnostic sensitivity, and aging. The prevalence of multiple...


Angiogenic factors: role in esophageal cancer, a brief review

Ladeira, Kátia; Macedo, Filipa; Longatto, Adhemar; Martins, Sandra

Esophageal cancer has an aggressive behavior with rapid tumor mass growth and frequently poor prognosis; it is known as one of the most fatal types of cancer worldwide. The identification of potential molecular markers that can predict the response to treatment and the prognosis of this cancer has been subject of a vast investigation in the recent years. Among several molecules, various angiogenic factors that ...


Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: r...

Macedo, Filipa; Ladeira, Kátia; Longatto, Adhemar; Martins, Sandra

Aim: Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to distant organ metastasis. The systemic chemotherapy has a minimal effect in peritoneal metastasis so new types of treatment have emerged. The authors revised the main studies done in pressurized intraperitoneal aerosol chemotherapy (PIPAC) and presented t...


Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progressi...

Macedo, Filipa; Ladeira, Kátia; Longatto, Adhemar; Martins, Sandra F.

Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: "Stomach neoplasms/blood [MeSH] or stomach neoplasms/bloo...


Fidedignidade inter e intra-juízes na medição da taxa diadococinética oral em c...

Macedo, Filipa; Grilo, Ana Margarida

Objetivo: O objetivo deste estudo é o de verificar a fidedignidade intra e inter-juízes na avaliação da taxa diadococinética oral, em dois momentos de avaliação (com duas semanas de intervalo). Métodos: Cinco terapeutas da fala avaliaram registos áudio (através do programa Audacity™ e de auscultadores SENNHEISER HD201) com cinco tarefas diadococinéticas (três ciclos monossilábicos, um ciclo dissilábico e um cic...



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