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Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats
Macedo, Francisco Yuri Bulcao; Baltazar, Fátima; Almeida, Paulo Roberto Carvalho; Távora, Fábio; Ferreira, Francisco Valdeci; Schmitt, Fernando C.Purpose Hemorrhagic cystitis (HC) is a limiting side effect of chemotherapy with ifosfamide (IFS). In this study, we investigated the participation of cyclooxygenase-2 (COX-2) upon ifosfamide-induced HC. Methods Male Wistar rats (150-200 g; six rats per group) were treated with saline, IFS (400 mg/kg, i.p.) and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters, and COX-2 expressi...
Date: 2008
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Origin: RepositóriUM - Universidade do Minho