28 documents found, page 1 of 3
Pan-Enteric Capsule Endoscopy: Current Applications and Future Perspectives
Rosa, Bruno; Andrade, Patrícia; Lopes, Sandra; Gonçalves, Ana Rita Marques; Serrazina, Juliana; Marílio Cardoso, Pedro; Silva, AndreaBackground: The role of capsule endoscopy in the evaluation of the small bowel is well established, and current guidelines position it as a first-line test in a variety of clinical scenarios. The advent of double-headed capsules further enabled the endoscopic assessment of colonic mucosa and the opportunity for a one-step noninvasive examination of the entire bowel (pan-enteric capsule endoscopy [PCE]). Summary...
Extracellular vesicles from pancreatic cancer stem cells lead an intratumor com...
Ruivo, Carolina F.; Bastos, Nuno; Adem, Barbara; Batista, Ines; Duraes, Cecilia; Melo, Carlos A.; Castaldo, Stephanie A.; Campos‐Laborie, FranciscoObjective: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour. Design: We have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). To determine th...
Severe acute autoimmune hepatitis: how to early predict who will not respond to...
João, Mafalda; Carvalhana, Sofia; Moura, Miguel; Freitas, Luís Carlos; Silva, Andrea; Figueiredo, Pedro; Liberal, Rodrigo; Macedo, GuilhermeBackround: In acute severe autoimmune hepatitis (AS-AIH), the early identification of predictors of non-response to corticosteroids and the optimal timing for liver transplantation (LT) remains controversial. Aims: To determine early predictors of non-response to corticosteroids and to assess the usefulness of severity scores, namely the recently developed SURFASA. Methods: Retrospective multicentre cohort stud...
Risk Stratification of Patients with Chronic Liver Disease and Potential Implic...
Tato Marinho, Rui; Matos, Leopoldo; Macedo, GuilhermeN/a.; N/a.
A consensus integrated care pathway for patients with primary biliary cholangit...
Hirschfield, Gideon M; Chazouillères, Olivier; Cortez-Pinto, Helena; Macedo, Guilherme; de Lédinghen, Victor; Adekunle, Femi; Carbone, MarcoIntroduction: Primary biliary cholangitis (PBC) is an infrequent, immune-mediated cholestatic liver disease, which can lead to liver fibrosis, cirrhosis and complications of end-stage liver disease. The established goals of treatment of PBC are prevention of end-stage liver disease and amelioration of associated symptoms. The European Association for the Study of the Liver (EASL) management guidelines provide e...
Elimination of Hepatitis C in Portugal: an urban legend?
Velosa, José; Macedo, GuilhermeThe burden of hepatitis C virus infection remains very high despite huge progress in the cure of the infection. The high prevalence of hepatitis C, especially in vulnerable groups and particularly drug users, may compromise the achievement of the 2030 WHO targets with a 90% reduction in new infections and a 65% reduction in mortality. Therapy with the latest pangenotypic direct-acting antivirals provides cure r...
Serum dipeptidyl peptidase 4 : a predictor of disease activity and prognosis in...
Pinto Lopes, Pedro; Afonso, Joana; Pinto Lopes, Rui; Rocha, Cátia; Lago, Paula; Gonçalves, Raquel; Tavares de Sousa, Helena; Macedo, GuilhermeBackground: Serum dipeptidyl peptidase 4 (DPP-4) has drawn particular interest as a biomarker in inflammatory bowel disease (IBD), as this protease inactivates several peptides that participate in the inflammatory cascade. Methods: Two prospectively recruited cohorts consisting of 195 patients (101 had Crohn’s disease [CD] and 94 had ulcerative colitis [UC]) were evaluated using clinical indexes and followed up...
Serum dipeptidyl peptidase 4: a predictor of disease activity and prognosis in ...
Pinto-Lopes, Pedro; Afonso, Joana; Pinto-Lopes, Rui; Rocha, Catia; Lago, Paula; Goncalves, Raquel; Sousa, Helena Tavares; Macedo, GuilhermeBackground: Serum dipeptidyl peptidase 4 (DPP-4) has drawn particular interest as a biomarker in inflammatory bowel disease (IBD), as this protease inactivates several peptides that participate in the inflammatory cascade. Methods: Two prospectively recruited cohorts consisting of 195 patients (101 had Crohn’s disease [CD] and 94 had ulcerative colitis [UC]) were evaluated using clinical indexes and followed up...
Dysphagia in a young female patient: it’s not always that simple
Carvão, Joana; Peixoto, Armando; Rios, Elisabete; Macedo, GuilhermeA 42-year- old female patient was referred to our gastroenterology department with a 4-month history of weekly symptoms of dysphagia for solids and liquids. The patient also reported occasional symptoms of food impaction and heartburn. She denied nausea, vomiting, weight loss or a recent change in bowel habits. The patient was not under any medication. Medical or surgical history was unremarkable. There was no ...
Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound: To Be...
Moutinho-Ribeiro, Pedro; Peixoto, Armando; Macedo, GuilhermeBACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) were initially introduced into the world of gastroenterology as purely diagnostic procedures. With progressive evolution of intervention, both these techniques conquered fields in the treatment of many conditions that had once been exclusively surgical domains. Nowadays, more and more clinical situations have an in...