9 documents found, page 1 of 1
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério César de Almeida; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.; Manadas, BrunoCoffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases
Sousa, Luís; Guarda, Mariana; Meneses, Maria João; Macedo, M. Paula; Vicente Miranda, HugoInsulin-degrading enzyme (IDE) function goes far beyond its known proteolytic role as a regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins such as amyloid-β peptide, glucagon, islet amyloid polypeptide (IAPP), and insulin-like growth factors, which have diverse physiological and pathophysiological functions. Importantly, IDE plays other non-proteolytic functions such a...
Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...
Borges, Diego O; Patarrão, Rita S; Ribeiro, Rogério T.; de Oliveira, Rita Machado; Duarte, Nádia; Belew, Getachew Debas; Martins, MadalenaSystemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...
Advancing the global public health agenda for NAFLD: a consensus statement
Lazarus, Jeffrey V.; Mark, Henry E.; Anstee, Quentin M.; Arab, Juan Pablo; Batterham, Rachel L.; Castera, Laurent; Cortez-Pinto, Helena; Crespo, JavierNon-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attentio...
Knockout of insulin-degrading enzyme leads to mice testicular morphological cha...
Meneses, Maria João; Borges, Diego O.; Dias, Tânia R.; Martins, Fátima O.; Oliveira, Pedro F.; Macedo, M. Paula; Alves, Marco G.Insulin-degrading enzyme (IDE) is a zinc metalloprotease responsible for degrading and inactivating several bioactive peptides, including insulin. Individuals without this enzyme or with a loss-of-function mutation in the gene that codifies it, present hyperinsulinemia. In addition, impairment of IDE-mediated insulin clearance is associated with the development of metabolic diseases, namely prediabetes. Althoug...
How Inflammation Impinges on NAFLD: A Role for Kupffer Cells
Duarte, Nádia; Coelho, Inês C.; Patarrão, Rita S.; Almeida, Joana I.; Penha-Gonçalves, Carlos; Macedo, M. PaulaNonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the ...
Disposition of [U-2H7]glucose into hepatic glycogen in rat and in seabass
Martins, Fátima O.; Rito, João; Jarak, Ivana; Viegas, Ivan; Pardal, M. A.; Macedo, M. Paula; Jones, John G.The stimulation of hepatic glycogenesis is a ubiquitous response to a glucose challenge and quantifying its contribution to glucose uptake informs its role in restoring euglycemia. Glycogenesis can be quantified with labeled water provided that exchange of glucose-6-phosphate hydrogen 2 (G6P-H2) and body water via glucose-6-phosphate isomerase, and exchange of positions 4, 5 and 6 hydrogens (G6P-H456) via trans...
Tonic activation of A2A adenosine receptors unmasks, and of A1 receptors preven...
Sebastião, Ana M; Macedo, M. Paula; Ribeiro, Joaquim A.We investigated how manipulations of the degree of activation of adenosine A1 and A2A receptors influences the action of the neuropeptide, calcitonin gene-related peptide (CGRP) on synaptic transmission in hippocampal slices. Field excitatory post-synaptic potentials (EPSPs) from the CA1 area were recorded. When applied alone, CGRP (1 - 30 nM) was without effect on field EPSPs. However, CGRP (10 - 30 nM) signif...