14 documents found, page 1 of 2
Significance of Furin Expression in Thyroid Neoplastic Transformation
Azevedo, Maria Teresa; Macedo, Sofia; Canberk, Sule; Cardoso, Luís; Gaspar, Tiago Bordeira; Pestana, Ana; Batista, Rui; Sobrinho-Simões, ManuelAngiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been th...
Generation of an obese diabetic mouse model upon conditional Atrx disruption
Gaspar, Tiago Bordeira; Jesus, Tito Teles; Azevedo, Maria Teresa; Macedo, Sofia; Soares, Mariana Alves; Martins, Rui Sousa; Leite, Rúben; Rodrigues, LiaATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homo...
High VEGFA expression Is associated with improved progression-free survival aft...
Alves, Bárbara; Peixoto, Joana; Macedo, Sofia; Pinheiro, Jorge; Carvalho, Bruno; Soares, Paula; Lima, Jorge; Lima, Raquel T.Glioblastoma (GB) is a deadly tumor that demands for relevant biomarkers, particularly regarding patients’ response to treatment. MMP-2, MMP-9, VEGFA, and YKL40 are important molecules, given their implication in the infiltrative and angiogenic phenotype of GBs. The purpose of this study was to assess the relationship between the expression of MMP-2, MMP-9, VEGFA, and YKL40 in GB tissues and the patients’ respo...
DGCR8 microprocessor subunit mutation and expression deregulation in thyroid le...
Rodrigues, Lia; Canberk, Sule; Macedo, Sofia; Soares, Paula; Vinagre, JoãoDeregulation of microRNA (miRNA) processing is a driver event in several tumours including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex component, and in the development of the thyroid. Previous studies identified a DGCR8 mutation – the variant c.1552G>A p.(E518K) – in cases of thyroid cancer and proposed to cause a familial syndr...
Post-COVID-19 condition: where are we now?
Boaventura, Paula; Macedo, Sofia; Ribeiro, Filipa; Jaconiano, Sónia; Soares, PaulaCOVID-19 is currently considered a systemic infection involving multiple systems and causing chronic complications. Compared to other post-viral fatigue syndromes, these complications are wider and more intense. The most frequent symptoms are profound fatigue, dyspnea, sleep difficulties, anxiety or depression, reduced lung capacity, memory/cognitive impairment, and hyposmia/anosmia. Risk factors for this condi...
Surface application of acidified cattle slurry compared to slurry injection: Im...
Fangueiro, David; Pereira, José Luís; Macedo, Sofia; Trindade, Henrique; Vasconcelos, Ernesto; Coutinho, JoãoIntensive cattle production has a severe environmental impact due, partly, to ammonia (NH3) and greenhouse gas emissions resulting from handling of the large amounts of slurry (liquid manure) produced. The present study aimed to compare, in terms of NH3, N2O, CH4 and CO2 emissions and crop yield, slurry injection in soil (reference technique) and a combined approach of slurry (S) treatment (by separation and/or...
C-33. Fibroma Ossificante Periférico: a propósito de um caso clínico
Godinho, Maria; Macedo, Sofia; Bexiga, Filipa; Lopes, Tinoco Torres; Mendes, Rui AmaralIntrodução: O mucocelo é uma das patologias benignas da cavidade oral, que pode atingir as glândulas salivares. Clinicamente a lesão é indolor, redonda, transparente e de cor azulada, com tamanho variável. A sua incidência é, na sua maioria em crianças ou jovens, sendo associada a episódios traumáticos, principalmente, das glândulas salivares minor, localizando-se preferencial na mucosa do lábio inferior. Caso ...
Indice de qualidade do planeamento em implantes de próstata
Coelho, Carina Marques; Resende, Sónia; Monsanto, Fátima; Sá, Ana Cravo; Trindade, Cândida; Macedo, SofiaEste estudo tem como objectivo a avaliação dos índices de qualidade nos implantes de braquiterapia prostática com sementes l125, em todos os doentes tratados com a técnica transperineal, no Instituto Português de Oncologia de Lisboa Dr. Francisco Gentil, EPE, desde Dezembro de 2007 a Abril de 2009.
Signs Workshop: the importance of natural gestures in the promotion of early co...
Almeida, Ana; Condeço, Teresa; Ramos, Fernando; Sousa, Álvaro; Cotrim, Luísa; Macedo, Sofia; Palha, MiguelThis article emphasises the importance of natural gestures and describes the framework and the development process of the “Signs Workshop” CD-ROM, which is a multimedia application for the promotion of early communication skills of children with developmental disabilities. Signs Workshop CD-ROM was created in the scope of Down’s Comm Project, which was financed by the Calouste Gulbenkian Foundation, and is the ...
Signs Workshop: promotion of early communication skills of children with develo...
Almeida, Ana Margarida; Sousa, Álvaro; Ramos, Fernando; Condeço, Teresa; Cotrim, Luísa; Macedo, Sofia; Palha, MiguelThis article presents and describes the framework and the development process of the “Signs Workshop” CD-ROM, which is a multimedia application for the promotion of early communication skills of children with developmental disabilities. Signs Workshop CD-ROM was created in the scope of Down’s Comm Project, which was financed by the Calouste Gulbenkian Foundation, and is the result of a partnership between UNICA...