4 documents found, page 1 of 1
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of i...
Marques, Marcia M.; Evangelista, Adriane F.; Macedo, Taciane; Vieira, Rene Aloisio da Costa; Scapulatempo-Neto, Cristovam; Reis, Rui M.OBJECTIVE: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer. ME...
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of i...
Marques, Marcia M.; Evangelista, Adriane F.; Macedo, Taciane; Vieira, René Aloisio da Costa; Scapulatempo-Neto, Cristovam; Reis, R. M.MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.
MicroRNA profiling in human breast cancer cell lines exposed to the anti-neopla...
Bordinhão, A. L. R.; Evangelista, Adriane F.; Oliveira, R. J. S.; Macedo, Taciane; Silveira, Henrique C. S.; Reis, R. M.; Marques, Marcia M. C.Cediranib, a pan-tyrosine kinase inhibitor is showing promising results for the treatment of several solid tumours. In breast cancer, its effects remain unclear, and there are no predictive biomarkers. Several studies have examined the expression profiles of microRNAs (miRNAs) in response to different chemotherapy treatments and found that the expression patterns may be associated with the treatment response. T...
MicroRNA expression as risk biomarker of breast cancer metastasis : a pilot ret...
Marino, Augusto L. F.; Evangelista, Adriane F.; Vieira, René A. C.; Macedo, Taciane; Kerr, Ligia M.; Machado, Lucas Faria AbrahãoBackground: MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis. In solid tumors, especially breast cancer, alterations in miRNA expression contribute to cancer pathogenesis, including metastasis. Considering the emerging role of miRNAs in metastasis, the identification of predictive markers is n...