30 documents found, page 1 of 3
A biocomplex to repair experimental critical size defects associated with photo...
Buchaim,Daniela Vieira; Andreo,Jesus Carlos; Pomini,Karina Torres; Barraviera,Benedito; Ferreira Júnior,Rui Seabra; Duarte,Marco Antonio HungaroAbstract Background: The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. The incorporation of particulate biomaterials into three-dimensional fibrin bioproducts together with photobiomodulation therapy (PBM) has potential and can improve regenerative medicine procedures. The objective of this experiment was to evaluate the effect...
Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon...
Hidd,Silvia Maria Cardoso Magalhães; Tim,Carla Roberta; Dutra Jr,Eneas de Freitas; Maia Filho,Antônio Luiz Martins; Assis,Lívia; Ferreira Jr,Rui SeabraABSTRACT Purpose The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. Methods Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histop...
Chronic venous ulcers: a review on treatment with fibrin sealant and prognostic...
Abbade,Luciana Patricia Fernandes; Ferreira Jr,Rui Seabra; Santos,Lucilene Delazari dos; Barraviera,BeneditoAbstract Venous ulcers are the main causes of chronic lower-limb ulcers. The healing difficulties encourage the research and development of new products in order to achieve better therapeutic results. Fibrin sealant is one of these alternatives. Besides being a validated scaffold and drug delivery system, it possesses excellent healing properties. This review covered the last 25 years of the literature and show...
Neuroprotection and immunomodulation by dimethyl fumarate and a heterologous fi...
Kempe,Paula R. G.; Chiarotto,Gabriela Bortolança; Barraviera,Benedito; Ferreira Jr.,Rui Seabra; Oliveira,Alexandre L. R. deAbstract Background: Ventral root avulsion (VRA) is an experimental approach in which there is an abrupt separation of the motor roots from the surface of the spinal cord. As a result, most of the axotomized motoneurons degenerate by the second week after injury, and the significant loss of synapses and increased glial reaction triggers a chronic inflammatory state. Pharmacological treatment associated with roo...
Fibrin biopolymer as scaffold candidate to treat bone defects in rats
Cassaro,Claudia Vilalva; Justulin Jr.,Luis Antonio; Lima,Patrícia Rodrigues de; Golim,Marjorie de Assis; Biscola,Natália PerussiABSTRACT Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an association of FBP, biphasic calcium phosphate (BCP) and mesench...
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaff...
Buchaim,Daniela Vieira; Cassaro,Claudia Vilalva; Shindo,João Vitor Tadashi Cosin; Coletta,Bruna Botteon Della; Pomini,Karina TorresAbstract Fibrin biopolymers, previously referred as “fibrin glue” or “fibrin sealants”, are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become widely used in medical and dental procedures. Historically, these biomaterials are produced from human fibrinogen and human or animal thrombin, and the possibility of tr...
Traceability of animal protein byproducts in ruminants by multivariate analysis...
Ferreira Jr.,Rui Seabra; Silva,Daniela Alessandra Fossato da; Biscola,Natália Perussi; Sartori,Maria Márcia Pereira; Denadai,Juliana CéliaAbstract Background: Ruminant feed containing animal byproduct proteins (ABPs) is prohibited in many countries due to its risk of transmitting prion diseases (PD). In most cases the entire herd is sacrificed, which causes great harm to the producer countries by preventing their exportation of ruminant derived-products. Methods: We used stable isotope ratio mass spectrometry (IRMS) of carbon (13C/12C) and nitrog...
Combination of heterologous fibrin sealant and bioengineered human embryonic st...
Mozafari,Roghayeh; Kyrylenko,Sergiy; Castro,Mateus Vidigal; Ferreira Jr,Rui Seabra; Barraviera,Benedito; Oliveira,Alexandre Leite RodriguesAbstract Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used. However, these surgical techniques result in nerve regeneration at highly variable degrees. It is thus very important to seek complementary techniques to improve motor an...
Multiple uses of fibrin sealant for nervous system treatment following injury a...
Biscola,Natalia Perussi; Cartarozzi,Luciana Politti; Ulian-Benitez,Suzana; Barbizan,Roberta; Castro,Mateus Vidigal; Spejo,Aline BarrosoAbstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The pos...
Heterologous fibrin sealant derived from snake venom: from bench to bedside – a...
Ferreira Jr,Rui Seabra; Barros,Luciana Curtolo de; Abbade,Luciana Patrícia Fernandes; Barraviera,Silvia Regina Catharino SartoriAbstract Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipit...