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Severe neonatal jaundice due to ade novoglucose-6-phosphate dehydrogenase defic...
Del Orbe Barreto, R.; Arrizabalaga, B.; de la Hoz, A. B; Aragües, P.; Garcia-Ruiz, J. C.; Arrieta, A.; Adán, R.; Manco, L.; Macedo-Ribeiro, S.
Date: 2016
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Origin: Estudo Geral - Universidade de Coimbra
Molecular and computational analyses of genes involved in mannose 6-phosphate i...
Coutinho, M.F.; Lacerda, L.; Pinto, E.; Ribeiro, H.; Macedo-Ribeiro, S.; Castro, L.; Prata, M.J.; Alves, S.The newly-synthesized lysosomal enzymes travel to the trans-Golgi network (TGN) and are then driven to the acidic organelle. While the best-known pathway for TGN-to-endosome transport is the delivery of soluble hydrolases by the M6P receptors (MPRs), additional pathways do exist, as showed by the identification of two alternative receptors: LIMP-2, implicated in the delivery of β-glucocerebrosidase; and sortili...
Date: 2014
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Origin: Repositório Científico do Instituto Nacional de Saúde