Regeneration of severe bone defects remains a challenge. A formulation of synthetic glass-reinforced hydroxyapatite bone substitute, Bonelike® Poro (BL®P), 250500 µm-diameter, with a dextrin-based hydrogel (HG), further loaded with human dental pulp stem cells (hDPSCs) with osteogenic differentiation ability, was tested for the management of critical-sized defects in an ovine model. Morphology, calcium release,...
Background: Escherichia coli is a commensal bacterium present in the gastrointestinal tract of warm-blood animals, and therefore routinely used as a microbiological indicator of fecal contamination [1,2]. However, several strains may acquire virulence factors, becoming potentially pathogenic for humans and animals [1,3]. Objective: The current study underscores human exposure to pathogenic and antimicrobial res...
Background: Myxozoans are a diverse group of cnidarian endoparasites cosmopolitan in the aquatic environment, responsible for causing serious diseases in fish [1]. Traditional methods of detection and characterization of these parasites are very cumbersome and complex by nature [1-3]. Therefore, it is essential to implement simpler, non-destructive approaches to assess myxozoan presence and diversity, such as e...
Issue/Problem: Mental disorders are the main cause of years lived with disability (YLD) in 5-14-year-old people around the world, in Western Europe, and particularly in Portugal. Young people who experience anxiety during childhood have a 3,5-fold likelihood of suffering from depression or anxiety during adulthood. COVID-19 has aggravated this situation, namely regarding socio-emotional competencies. Descriptio...
This work presents the first results of the iconographic study and analytical characterisation of a set of four stained-glass panels that are part of the collection of National Palace of Pena (Sintra, Portugal). These panels were collected by the King Ferdinand II in the mid-nineteenth century, for his main residence the Palace of Necessidades (Lisbon, Portugal), and only first presented to the general public i...
This scoping review summarized the evidence regarding the impact of acute exacerbations of COPD (AECOPD) on patients' health status beyond pulmonary function. PubMed, Embase, and Web of Science were searched. Prospective cohort studies assessing the health status of patients with COPD in a stable phase of the disease and after a follow-up period (where at least one AECOPD occurred) were included. An integrated ...
Introduction: Interstitial lung diseases (ILD) comprehend a large group of lung diseases that include disease settings associated with sustained progression and leading to respiratory failure, decreased functional status and premature death. Functional status can be defined as an individual’s ability to perform normal daily activities required to meet basic needs, fulfill usual roles and maintain health and wel...
Introduction: Functional status is a key outcome in people with chronic obstructive pulmonary disease (COPD) and can be defined as an individual’s ability to perform normal daily activities required to meet basic needs, fulfill usual roles, and maintain health and well-being. The 1-minute sit-to-stand test (1-min STS) is a wellestablished measure to assess functional status in people with COPD that can be used ...
Objectives: The ABCD assessment tool (ABCD) proposed by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) is often used to guide treatment in chronic obstructive pulmonary disease (COPD). However, treatment remains focused on pulmonary pharmacology, despite being known that this will have minimal effects on meaningful aspects of people’s daily life such as symptoms. Pulmonary rehabilitation (PR)...