7 documents found, page 1 of 1
The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA ...
Machado, Carlos Renato
Early polymerase chain reaction detection of Chagas disease reactivation in hea...
Costa, Priscilla Almeida da; Segatto, Marcela [UNESP]; Durso, Danielle Fernandes; Carvalho Moreira, Wagson Jose de; Junqueira, Lucas LodiMade available in DSpace on 2018-11-26T15:44:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-07-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Departamento de Ciencia e Tecnologia do Ministerio da Saude (Decit/SCTIE/MS); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); BACKGROUND: Heart tr...
Replication Protein A Presents Canonical Functions and Is Also Involved in the ...
Pavani, Raphael Souza; da Silva, Marcelo Santos; Fernandes, Carlos Alexandre Henrique [UNESP]; Morini, Flavia Souza; Araujo, Christiane BezerraMade available in DSpace on 2018-12-11T17:08:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-12-16; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Replication Protein A (RPA), the major single stranded DNA binding protein in eukaryotes, is composed of three subunits and is a fundamental player in DNA metabolism, part...
Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome...
Cerqueira, Paula Gonçalves; Silva, Danielle Gomes Passos; Rocha, João Pedro Vieira da; Mendes, Isabela Cecilia; Oliveira, Karla Andrade detIn recent years, proteasome involvement in the damage response induced by ionizing radiation (IR)became evident. However, whether proteasome plays a direct or indirect role in IR-induced damageresponse still unclear. Trypanosoma cruzi is a human parasite capable of remarkable high tolerance toIR, suggesting a highly efficient damage response system. Here, we investigate the role of T. cruzi pro-teasome in the ...
Genetic profiling of Trypanosoma cruzi directly in infected tissues using neste...
Pimenta, Juliana Ramos; Freitas, Jorge Marcelo de; Duffy, Tomás; Bartholomeu, Daniella Castanheira; Oliveira, Riva de Paula; Chiari, EglerThe investigation of the importance of the genetics of Trypanosoma cruzi in determining the clinical course of Chagas disease will depend on precise characterisation of the parasites present in the tissue lesions. This can be adequately accomplished by the use of hypervariable nuclear markers such as microsatellites. However the unilocal nature of these loci and the scarcity of parasites in chronic lesions make...
Unveiling benznidazole's mechanism of action through overexpression of DNA repa...
Machado, Carlos Renato
Unequivocal identification of subpopulations in putative multiclonal Trypanosom...
Valadares, Helder Magno Silva; Pimenta, Juliana Ramos; Segatto, Marcela; Veloso, Vanja Maria; Gomes, Mônica Lúcia; Chiari, Egler; Gollob, Kenneth JohnTrypanosoma cruzi, the etiological agent of Chagas disease, is a polymorphic species. Evidence suggests that the majority of the T. cruzi populations isolated from afflicted humans, reservoir animals, or vectors are multiclonal. However, the extent and the complexity of multiclonality remain to be established, since aneuploidy cannot be excluded and current conventional cloning methods cannot identify all the r...