40 documents found, page 1 of 4
Emergence of Multidrug-Resistant Mycobacterium Tuberculosis of the Beijing Line...
Perdigão, J; Silva, C; Maltez, F; Machado, D; Miranda, A; Couto, I; Rabna, P; Florez de Sessions, P; Phelan, J; Pain, A; McNerney, R; Hibberd, MThe Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Nevertheless, recent data shows that this genotype might be gradually emerging in these two countries as...
The membrane periodic skeleton is an actomyosin network that regulates axonal d...
Costa, AR; Sousa, SC; Pinto-Costa, R; Mateus, JC; Lopes, CDF; Costa, AC; Rosa, D; Machado, D; Pajuelo, L; Wang, X; Zhou, FQ; Pereira, AJ; Sampaio, PNeurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain-and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that controls axonal expansion and contraction. Using super-resolution microscopy, we analyzed the localization of axonal non-muscle myosin II (NMII). We show that active...
Using Genomics to Understand the Origin and Dispersion of Multidrug and Extensi...
Perdigão, J; Gomes, P; Miranda, A; Maltez, F; Machado, D; Silva, C; Phelan, J; Brum, L; Campino, S; Couto, I; Viveiros, M; Clark, T; Portugal, IPortugal is a low incidence country for tuberculosis (TB) disease. Now figuring among TB low incidence countries, it has since the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predominantly by two strain-types: Lisboa3 and Q1. This study describes the largest characterization of the evolutionary trajectory of M/XDR-TB strains in Portugal, spanning a time-period of two...
High-Grade Urothelial Carcinoma in a Kidney Transplant Recipient After JC Virus...
Querido, S; Fernandes, I; Weigert, A; Casimiro, S; Albuquerque, C; Ramos, S; Adragão, T; Luz, I; Paixão, P; Chasqueira, M; Santos, M; Machado, DKidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation...
Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum
Cá, B; Fonseca, KL; Sousa, J; Maceiras, AR; Machado, D; Sanca, L; Rabna, P; Rodrigues, P; Viveiros, M; Saraiva, MTuberculosis remains a public health problem and a main cause of death to humans. Both Mycobacterium tuberculosis and Mycobacterium africanum cause tuberculosis. In contrast to M. tuberculosis, which is geographically spread, M. africanum is restricted to West Africa. Differences have also been found in the growth rate and type of disease caused by M. africanum, globally suggesting an attenuation of this bacter...
IgA nephropathy in a young adult with nephrotic syndrome: Case report
Cassis, J; Sousa, H; Manso, RT; Ramos, S; Machado, DIgA nephropathy has many clinical presentations, of which nephrotic syndrome is possibly the rarest. Recently, the association of IgA nephropathy with minimal change disease was better described with patients having complete response to steroid therapy and no progression to CKD. We report a similar case in a young male presenting with nephrotic syndrome.
IgA nephropathy in a young adult with nephrotic syndrome: Case report
Cassis, J; Sousa, H; Manso, RT; Ramos, S; Machado, DIgA nephropathy has many clinical presentations, of which nephrotic syndrome is possibly the rarest. Recently, the association of IgA nephropathy with minimal change disease was better described with patients having complete response to steroid therapy and no progression to CKD. We report a similar case in a young male presenting with nephrotic syndrome.
Prevalence of bacterial vaginosis in Portuguese pregnant women and vaginal colo...
Machado, D; Castro, J; Martinez-de-Oliveira, J; Nogueira-Silva, C; Cerca, NBACKGROUND: We aimed to determine the prevalence of vaginal colonization by Gardnerella vaginalis and of bacterial vaginosis (BV) in Portuguese pregnant women, and to identify risk factors for BV and G. vaginalis colonization in pregnancy. METHODS: A cross-sectional study was conducted among pregnant women aged ≥ 18 years who were attending in two public hospitals of the Northwest region of Portugal. Epidemiolo...
Benefits of Selective Vitamin D Receptor Activators in Kidney Transplanted Pati...
Ferreira, A; Aires, I; Nolasco, F; Machado, D; Macário, F; Neves, PL; Costa, AG; Cabrita, AMN; Castro, R; Pereira, JBSevere chronic kidney disease may lead to disturbances, such as hyperphosphatemia, increased secretion of fibroblast growth factor -23 (FGF -23) and vitamin D deficiency. These may increase plasmatic levels of parathyroid hormone, and decrease plasmatic levels of calcium. Altogether, these may contribute to the development of secondary hyperparathyroidism, and to abnormalities in mineral metabolism. Kidney tran...
Renal Transplantation in HIV-Infected Patients: The First Portuguese Review
Querido, S; Machado, D; Silva, C; Nolasco, F; Nunes, A; Sampaio, S; Cruz, P; Oliveira, C; Weigert, AINTRODUCTION: With the introduction of combination antiretroviral therapy (cART), prognosis of human immunodeficiency virus (HIV) infection has been improved and kidney transplantation (KT) in HIV-positive patients became possible. METHODS: We reviewed the demographic, clinical, laboratory, and therapeutic data of all the HIV-infected patients who underwent KT between 2009 (first KT in Portugal in a HIV-infecte...