38 documents found, page 1 of 4
Itinerário Geobotânico aos Habitats Dunares do Território Sadense
Sá, Diogo; Portugal Ferreira, Luís; Baião, Cristina; Machado, Mariana; Pinto Gomes, Carlos; Meireles, CatarinaO presente trabalho, desenvolvido no âmbito do seminário conjunto do XVI Seminário Internacional de Gestão e Conservação da Biodiversidade e do Primeiro Seminário do projeto Zimbral for LIFE, tem como objetivo identificar, ainda que de forma sucinta, a flora e vegetação psamófila do Distrito biogeográfico Sadense, dando especial destaque aos zimbrais dunares costeiros. Este território português singular, caract...
The growing landscape of NAFLD-associated hepatocellular carcinoma and Its impa...
Machado, MarianaLiver cancer is globally the third leading cause of death from cancer. Hepatocellular carcinoma (HCC) develops in patients with underlying liver disease. The fraction of HCC attributed to nonalcoholic fatty liver disease (NAFLD) shows an accelerated increase in the last decades, being already responsible for 15% of all HCC cases. Similar to other causes of liver cirrhosis, patients with NAFLD-associated cirrhos...
The neuroprotective effect of traditional chinese medicinal plants—A critical r...
Moreira, João; Machado, Mariana; Dias-Teixeira, Mónica; Ferraz, Ricardo; Delerue-Matos, Cristina; Grosso, ClaraNeurodegenerative and neuropsychiatric diseases are increasingly affecting individuals’ quality of life, thus increasing their cost to social and health systems. These diseases have overlapping mechanisms, such as oxidative stress, protein aggregation, neuroinflammation, neurotransmission impairment, mitochondrial dysfunction, and excitotoxicity. Currently, there is no cure for neurodegenerative diseases, and t...
MASLD treatment : a shift in the paradigm is imminent
Machado, MarianaMASLD prevalence is growing towards the leading cause of end-stage liver disease. Up to today, the most effective treatment is weight loss. Weight loss interventions are moving from lifestyle changes to bariatric surgery or endoscopy, and, more recently, to a new wave of anti-obesity drugs that can compete with bariatric surgery. Liver-targeted therapy is a necessity for those patients who already present liver...
Hepatocellular carcinoma screening in NAFLD: the paradox of nearly half the cas...
Machado, MarianaLiver cancer is in the top three leading causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 85% of primary liver cancers and develops in patients with chronic liver disease (CLD). The progressive increase in the prevalence of nonalcoholic fatty liver disease (NAFLD), which recently reached up to 30% of the global population, and the recent effective treatment for hepatitis C, res...
New developments in celiac disease treatment
Machado, MarianaCeliac disease (CD) is a common autoimmune disease affecting around 1% of the population. It consists of an immune-mediated enteropathy, triggered by gluten exposure in susceptible patients. All patients with CD, irrespective of the presence of symptoms, must endure a lifelong gluten-free diet (GFD). This is not an easy task due to a lack of awareness of the gluten content in foods and the extensive incorporati...
O marketing sensorial na otimização da experiência, conexão emocional e lealdad...
Machado, MarianaO marketing sensorial assume-se como uma estratégia positivamente impactante no envolvimento do consumidor com a marca. A presente dissertação tem como finalidade perceber de que modo são implementadas estratégias de marketing sensorial e se existe um contributo das mesmas para a melhoria da experiência, conexão emocional e lealdade do consumidor à marca. Foi adotada a metodologia de abordagem qualitativa, reco...
Rotor syndrome presenting as Dubin-Johnson syndrome
Morais, Mariana B; Couvert, Philippe; Jéru, Isabelle; Machado, MarianaA 42-year-old man with no relevant past medical history presented with intermittent mild icterus and no signs of chronic liver disease. Laboratory tests were notable for hyperbilirubinemia (total 7.97 mg/dL, direct 5.37 mg/dL), bilirubinuria, no signs of hemolysis, normal liver tests and lipids profile. Abdominal ultrasound was unremarkable. A panel of chronic liver diseases was negative except for increased se...
Benign inheritable disorders of bilirubin metabolism manifested by conjugated h...
Morais, Mariana B; Machado, MarianaBilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. Hyperbilirubinemia is an important clinical sign that needs to be investigated under a stepwise evaluation. Inherited non-hemolytic conjugated hyperbilirubinemic conditions include Dubin-Johnson syndrome ...
NAFLD nutritional management: results from a multidisciplinary approach
Policarpo, Sara; Machado, Mariana; Pires Barreira, David; Cortez-Pinto, HelenaIntroduction: Lifestyle changes are the mainstay treatment of nonalcoholic fatty liver disease (NAFLD). We aimed to assess the magnitude of weight loss in a group of NAFLD patients followed on a combined lifestyle intervention by a multidisciplinary team. Methods: Patients were assessed before and after a 12-month dietary intervention (Mediterranean diet aiming at weight loss). Patients who received a structure...