Background: Obesity is a progressive and relapsing chronic disease with serious health consequences and is recognized as a major global public health concern. In Europe, over half of the adult population is classified as overweight, with obesity rates around 17%—a figure consistent with data from Portugal. Achieving and maintaining weight loss (WL) remains a significant challenge. First-line interventions such ...
Introduction – Myocardial Perfusion Imaging (MPI) by single-photon emission computed tomography (SPECT) is one of the most widely used Non-invasive imaging tests in the diagnosis of coronary artery disease that requires correct segmentation of the left ventricle (LV), to extract perfusion parameters. The aim of this study is to evaluate the influence of automatic (A) vs. manual (M) segmentation in the quantific...
Lately, several studies have demonstrated the health benefits associated with natural compounds consumption. Fruit phenolics, lycopene and ascorbic acid, have strong antioxidant, anti-inflammatory, antimugenic and anticarcinogenic activities. In the present study parameters related to fruit quality and climacteric conditions, such as color, moisture, pH, water activity, total phenolic compounds, ascorbic acid a...
Background and objectives: Leishmania species is the causative agent of leishmaniasis, a broad-spectrum clinical condition that can even be life-threatening when neglected. Current therapeutic strategies, despite beings highly cost-e ective, have been increasingly associated with the appearance of drug-resistant microorganisms. Thus, an increasing number of thorough studies are needed towards upcoming drug disc...
Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is important for risk stratification of coronary artery disease. MPI quantification obtained from available images may not be accurate due to several potential sources of error, being photon attenuation, especially in overweight patients, a significant problem. Attenuation maps derived from X-ray computed tomography (CT) ...
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Leishmaniosis is a neglected tropical disease which affects several millions of people worldwide. The current drug therapies are expensive and often lack efficacy, mainly due to the development of parasite resistance. Hence, there is an urgent need for new drugs effective against Leishmania infections. As a part of our ongoing study on the phytochemical characterization and biological investigation of plants us...
Introdução – A cintigrafia de perfusão do miocárdio (CPM) por tomografia por emissão de fotão único (SPECT, do acrónimo inglês single-photon emission computed tomography) é um dos exames mais utilizados na estratificação do risco de doença coronária, cuja extração dos parâmetros quantitativos da perfusão do miocárdio depende da correta segmentação do ventrículo esquerdo (VE). O objetivo deste estudo é avaliar a...